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PathCaseMAW: A Workbench for Metabolomic Analysis

D'Souza, Arun
http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452

Abstract Details

2009, Master of Sciences, Case Western Reserve University, EECS - Computer and Information Sciences.
The emerging area of Metabolomics provides new paradigms for diagnosis of diseases by rapidly and non-invasive providing specific bio-markers, useful for the diagnosis of early stages of diseases, and indicators of action sites of drugs. Emerging technologies are continuously increasing the number of metabolites that can be detected. Now there exists a need for computational tools to help clinical researchers to derive meaningful interpretations of metabolomics data. In this thesis we propose a metabolomic analysis workbench called PathCaseMAW which provides (1) A web accessible metabolic pathway database which supports online browsing and querying, and is novel in that it includes location information for pathways and also models transport processes. (2) Tissue-aware visualization support for viewing process, pathways or groups of pathways from our database. (3) An online tool which allows users to upload their own observed/measured metabolite level changes and computationally identifies the mechanisms that produce those metabolite changes.
Gultekin Ozsoyoglu, PhD (Committee Chair)
Meral Ozsoyoglu, PhD (Committee Member)
Mehmet Koyuturk, PhD (Committee Member)
100 p.
Biochemistry; Computer Science
Metabolomics; pathway databases; hypothesis generation; interpretation; closure tree

Recommended Citations

Citations

  • D'Souza, A. (2009). PathCaseMAW: A Workbench for Metabolomic Analysis [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452

    APA Style (7th edition)

  • D'Souza, Arun. PathCaseMAW: A Workbench for Metabolomic Analysis. 2009. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452.

    MLA Style (8th edition)

  • D'Souza, Arun. "PathCaseMAW: A Workbench for Metabolomic Analysis." Master's thesis, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452

    Chicago Manual of Style (17th edition)

case1222895452
978
© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.