Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1201202472.pdf (2.47 MB)

ETD Abstract Container

Abstract Header

STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA

Ramakrishnan, Devi Prasadh
http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Biochemistry.
Chronic intermittent hypoxia (CIH) augments norepinephrine (NE) efflux to acute hypoxia in adult rat adrenal medulla (AM). Neuropeptide-Y (NPY) is shown to be co-stored with NE and facilitate its release from AM through NPY-Y1 receptor. This study examines if CIH alters NPY efflux from adult rat AM and, if so, by what mechanism(s), and the effect of NPY on CIH induced increase in blood pressure. NPY and NE effluxes were studied from ex vivo AM. Results of this study show that while acute hypoxia and acidic hypercapnia augments NPY efflux, isohydric hypercapnia and nicotine inhibited NPY efflux in CIH exposed AM. NPY, by facilitating NE efflux through NPY-Y1 receptor, contributes to CIH induced blood pressure raise. Antioxidant treatment restored the nicotine-evoked and inhibited acute hypoxia-evoked NPY efflux from AM of rats exposed to CIH suggesting mechanisms involving oxidant radicals are responsible for CIH induced alterations in NPY efflux.
GANESH KUMAR (Advisor)
70 p.
CIH; NPY; EFFLUX; ADRENAL; NPY-LI; NPY-LI efflux; HYPOXIA

Recommended Citations

Citations

  • Ramakrishnan, D. P. (2008). STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472

    APA Style (7th edition)

  • Ramakrishnan, Devi Prasadh. STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472.

    MLA Style (8th edition)

  • Ramakrishnan, Devi Prasadh. "STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472

    Chicago Manual of Style (17th edition)

case1201202472
1,907
© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.