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THE ROLE OF THE INSULIN GROWTH FACTOR FAMILY IN DEVELOPMENT OF BARRETT’S ESOPHAGUS: A CASE-CONTROL STUDY

Greer, Katarina Brenkusova
http://rave.ohiolink.edu/etdc/view?acc_num=case1244125383

Abstract Details

2009, Master of Sciences, Case Western Reserve University, Clinical Research.
Obesity is a well established risk factor for Barrett’s esophagus (BE). The mechanisms by which obesity leads to development of BE are not completely understood. High levels of insulin and IGF-1 were hypothesized to provide the link between obesity and BE. A case-control study comparing BE cases with controls with respect to measures of adiposity, levels of serum insulin as well as insulin growth factor proteins was conducted. The activation of the insulin signaling pathway was further assessed by immunohistochemistry of tissues obtained from BE cases. High serum insulin was associated with increased risk of BE, whereas high levels of IGFBP-3 were associated with decreased risk of BE. There was no demonstrable correlation between serum factors and tissue activation of phosphorylated insulin receptor substrate-1. Insulin signaling pathway is likely active in esophageal tumorigenesis. Further studies are needed to explore the complex interactions of this pathway with other molecular pathways activated by excess body weight.
Amitabh Chak, MD (Committee Chair)
Barbara Cromer, MD (Advisor)
Greg Cooper, MD (Committee Member)
Li Li, MD/PhD (Committee Member)
41 p.
Anatomy and Physiology; Biomedical Research
insulin obesity Barrett's esophagus

Recommended Citations

Citations

  • Greer, K. B. (2009). THE ROLE OF THE INSULIN GROWTH FACTOR FAMILY IN DEVELOPMENT OF BARRETT’S ESOPHAGUS: A CASE-CONTROL STUDY [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1244125383

    APA Style (7th edition)

  • Greer, Katarina. THE ROLE OF THE INSULIN GROWTH FACTOR FAMILY IN DEVELOPMENT OF BARRETT’S ESOPHAGUS: A CASE-CONTROL STUDY. 2009. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1244125383.

    MLA Style (8th edition)

  • Greer, Katarina. "THE ROLE OF THE INSULIN GROWTH FACTOR FAMILY IN DEVELOPMENT OF BARRETT’S ESOPHAGUS: A CASE-CONTROL STUDY." Master's thesis, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244125383

    Chicago Manual of Style (17th edition)

case1244125383
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© 2009, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.