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Acute exercise effects on cardiac gene expression in physically active and inactive rats

Simonsen, Michelle L.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1272053141

Abstract Details

2010, Master of Science, Miami University, Physical Education, Health, and Sport Studies.
Acute exercise may affect health-associated gene expressions and phenotypes differently depending on whether the individual exercises regularly. One-month old male Sprague-Dawley rats (n=72) were divided into SED (standard laboratory cage, n=24), PA (large box, n=24), and EX (running wheel inside standard cage, n=24). At three months, half from each group were sacrificed at rest and half following 30 minutes of acute exercise. RNA was extracted from cardiac tissue. Microarray analysis was performed on 27,000 genes and qPCR on select genes. Of the 1.9% genes that were differentially expressed (p<0.05), 37 unique and identifiable genes were > or equal to 2-fold. The genes Atf3, Fos, Apold1, and Pxdn were expressed differently among SED, PA and EX following acute exercise, with a clear separation of the magnitude in gene expression of SED > PA > EX. Some genes have regulatory effects on blood lipids and body weight, with healthier phenotypes in the more active groups.
Dr. Helaine M. Alessio, PhD (Advisor)
Dr. Ann E. Hagerman, PhD (Committee Member)
Dr. Randal Claytor, PhD (Committee Member)
37 p.
Animals; Biochemistry; Biomedical Research; Cellular Biology; Chemistry; Genetics; Health
acute exercise; gene expression; physical activity; inactivity; cardiac

Recommended Citations

Citations

  • Simonsen, M. L. (2010). Acute exercise effects on cardiac gene expression in physically active and inactive rats [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1272053141

    APA Style (7th edition)

  • Simonsen, Michelle. Acute exercise effects on cardiac gene expression in physically active and inactive rats. 2010. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1272053141.

    MLA Style (8th edition)

  • Simonsen, Michelle. "Acute exercise effects on cardiac gene expression in physically active and inactive rats." Master's thesis, Miami University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1272053141

    Chicago Manual of Style (17th edition)

miami1272053141
416
© 2010, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.