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Influence of Exercise Training on Oxidative Capacity and Utrastructural Damage in Skeletal Muscles of Aged Horses

Kim, Jeong-su
http://rave.ohiolink.edu/etdc/view?acc_num=osu1035562999

Abstract Details

2002, Doctor of Philosophy, Ohio State University, Physical Activity and Educational Services.
During the aging process there is a progressive decrease in the ability of skeletal muscle to generate and sustain force and power, and these functional adaptations occur in concert with profound morphological and biochemical adaptations. The purpose of the present study was to determine 1) the age-related changes in myosin heavy chain (MHC) composition and muscle oxidative and glycolytic capacity in 18 horses ranging in age from 2 to 30 years and 2) the effect of 10 weeks of treadmill exercise training on muscle oxidative capacity and ultrastructural damage in 6 aged female Quarter horses (>23 years). There was no significant correlation between horse age and the proportions of type-IIA and type-IIX MHC isoforms (r = 0.2 and -0.03, respectively, P > 0.05). The percent of type-I MHC isoforms decreased with advancing age (r = -0.56, P < 0.05). Muscle citrate synthase (CS) activity decreased with aging (r = -0.41, P < 0.05), whereas lactate dehydrogenase (LDH) activity increased (r = 0.44, P < 0.05). However, muscle 3-OH acyl COA dehydrogenase (HAD) activity did not change with aging (r = 0.11, P > 0.05). Maximal aerobic capacity (VO2max) increased by 22% after 10 weeks of training. After training, the percent of type-IIA MHC isoforms increased (11%, P < 0.05) while the percent of type-IIX MHC isoforms significantly decreased (3%, P < 0.05). Triceps muscle showed significant increases (P < 0.05) in both CS and HAD activities by 41% and 72% after training, respectively. Attenuation of the exercise-induced ultrastructural muscle damage at both the same absolute and the same relative workloads after exercise training occurred only in the semimembranosus muscle. The results of the present study suggest that age-related changes in equine skeletal muscle may differ from those in humans. However, similar to humans, the oxidative capacity of equine skeletal muscle appears to decrease with age, but intense aerobic exercise training can overcome this age-related reduction in functional capacity. This finding is consistent with a training-induced transition of MHC isoforms in aged skeletal muscle that shifts toward more oxidative after training. Electron microscopic analysis provides evidence that aerobic exercise training can attenuate the severity of the exercise-induced ultrastructural damage in aged skeletal muscle at given absolute and/or at the same relative workloads. However, the exercise training-induced adaptations in mammalian skeletal muscle may be muscle-group specific.
Steven Devor (Advisor)
Biology, Cell; Gerontology
Aging; equine skeletal muscle; Citrate synthase; 3-OH acyl COA dehydrogenase; lactate dehydrogenase; Exercise-induced ultrasktructural muscle damage; electron microscope; Myosin heavy chain

Recommended Citations

Citations

  • Kim, J.-S. (2002). Influence of Exercise Training on Oxidative Capacity and Utrastructural Damage in Skeletal Muscles of Aged Horses [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1035562999

    APA Style (7th edition)

  • Kim, Jeong-su. Influence of Exercise Training on Oxidative Capacity and Utrastructural Damage in Skeletal Muscles of Aged Horses. 2002. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1035562999.

    MLA Style (8th edition)

  • Kim, Jeong-su. "Influence of Exercise Training on Oxidative Capacity and Utrastructural Damage in Skeletal Muscles of Aged Horses." Doctoral dissertation, Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1035562999

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.