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Tetracycline Resistance in Adult Human Gastrointestinal Microflora - Can It Tell the Story of Antibiotic Resistance in Humans?

Cortado, Hanna Hifarva
http://rave.ohiolink.edu/etdc/view?acc_num=osu1213366360

Abstract Details

2008, Master of Science, Ohio State University, Food Science and Nutrition.
Antibiotic resistance (AR) in pathogens is a worldwide human health concern. The potential of food and enteric commensals as carriers of AR determinants to humans need to be clarified. Gastrointestinal microflora of 14 healthy individuals were examined for the presence of tetracycline-resistant bacteria and tetracycline-resistance genes. Results revealed a resistant count ranging from 106-109 CFU-mL-1, with non-resistant counts ranging from 106-1010 CFU-mL-1. The tetM gene pool determined by TaqMan real-time polymerase chain reaction ranged from 107-109 tetM gene copy number per gram. From the isolates examined, 8 distinct plasmid profiles were observed. DNA-DNA hybridization indicated the plasmid carriage of the tetM gene in some of the isolates. The regular inoculation of the colon with ART bacteria through the food chain is hypothesized as a significant contributor towards the enrichment of antibiotic resistant ART isolates and AR genes in the gut.
Hua Wang, PhD (Advisor)
Macdonald Wick, PhD (Committee Member)
Jeff Culbertson, PhD (Committee Member)
80 p.
Food Science
tetracycline resistance; antibiotic resistance; tetracycline; human gastrointestinal tract; food commensal

Recommended Citations

Citations

  • Cortado, H. H. (2008). Tetracycline Resistance in Adult Human Gastrointestinal Microflora - Can It Tell the Story of Antibiotic Resistance in Humans? [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213366360

    APA Style (7th edition)

  • Cortado, Hanna. Tetracycline Resistance in Adult Human Gastrointestinal Microflora - Can It Tell the Story of Antibiotic Resistance in Humans? 2008. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1213366360.

    MLA Style (8th edition)

  • Cortado, Hanna. "Tetracycline Resistance in Adult Human Gastrointestinal Microflora - Can It Tell the Story of Antibiotic Resistance in Humans?" Master's thesis, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213366360

    Chicago Manual of Style (17th edition)

osu1213366360
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© 2008, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.