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osu1306811234.pdf (457.32 KB)
ETD Abstract Container
Abstract Header
A differential equation model of Ets2 driven bistability of TFG-beta concentration
Author Info
Young, Alexander L.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1306811234
Abstract Details
Year and Degree
2011, Master of Science, Ohio State University, Mathematics.
Abstract
Fully understanding the development of a cancer within an organism requires detailed understanding on interactions taking place within the microenvironments of individual cells. Cancer formation requires not only growth of cancerous epithelial cells but also changes to the immune and mesenchymal cells in the neighborhood of the tumor. Without environmental changes tumor restructuring and angiogenesis needed for a tumor to fully develop, the cancer would not pose a severe threat. A primary mechanism for controlling said angiogenesis and stoma restructuring is in the cytokine family of transforming growth factor beta. In this paper the activity of the regulatory gene Ets2 and its effects on transforming growth factor beta through macrophage and fibroblasts will be studied via a system of ordinary differential equations. The ODEs will demonstrate the potential for Ets2 to act as an intermediate in an autocatalytic pathway that can drive TGFb to heightened levels necessary for the promotion of tumorigenesis.
Committee
Avner Friedman (Advisor)
Michael Ostrowski (Committee Member)
Pages
35 p.
Subject Headings
Mathematics
Keywords
Transforming growth factor beta
;
Ets2
;
differential equations
;
cancer
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Citations
Young, A. L. (2011).
A differential equation model of Ets2 driven bistability of TFG-beta concentration
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306811234
APA Style (7th edition)
Young, Alexander.
A differential equation model of Ets2 driven bistability of TFG-beta concentration.
2011. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1306811234.
MLA Style (8th edition)
Young, Alexander. "A differential equation model of Ets2 driven bistability of TFG-beta concentration." Master's thesis, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306811234
Chicago Manual of Style (17th edition)
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Document number:
osu1306811234
Download Count:
480
Copyright Info
© 2011, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.