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Thesis_CHDurney.pdf (1.2 MB)
ETD Abstract Container
Abstract Header
A Two-Component Model For Bacterial Chemotaxis
Author Info
Durney, Clinton H
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1366312981
Abstract Details
Year and Degree
2013, Master of Science, Ohio State University, Mathematics.
Abstract
Chemotaxis is the directed cell movement in response to chemical signals. It is crucial in many multicellular processes, such as wound healing, cancer metastasis, embryonic development and bioremediation. Quantitative descriptions of chemotaxis will lead to a better understanding of the mechanisms of chemotaxis and is essential in understanding the aforementioned processes. In this thesis, we study chemotaxis of the run-and-tumble bacteria
E. coli
. We develop a mathematical model of
E. coli
chemotaxis at the single cell level. The model consists of two modules: The first describes how the cell transduces the external signal into an internal signal (i.e. the change of the concentration of the intracellular protein CheY
P
). Our description is based on an existing "trimers of dimers" model and we improve the parameter estimation in this work. The second module is the change of cell movement in response to the internal CheY
P
change. We propose a new method to interpret existing data on flagellar rotation. Finally we couple these two modules and use the full model to simulate a population of cells.
Committee
Chuan Xue, Dr. (Advisor)
Ching-Shan Chou, Dr. (Committee Member)
Daniel Wozniak, Dr. (Committee Member)
Pages
51 p.
Subject Headings
Applied Mathematics
;
Biology
Keywords
Mathematical Biology
;
Chemotaxis
;
Mathematical Modelling
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Citations
Durney, C. H. (2013).
A Two-Component Model For Bacterial Chemotaxis
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366312981
APA Style (7th edition)
Durney, Clinton.
A Two-Component Model For Bacterial Chemotaxis.
2013. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1366312981.
MLA Style (8th edition)
Durney, Clinton. "A Two-Component Model For Bacterial Chemotaxis." Master's thesis, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366312981
Chicago Manual of Style (17th edition)
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Document number:
osu1366312981
Download Count:
1,382
Copyright Info
© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.