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Formulation of a fast-acting ibuprofen suspension by using nicotinamide as hydrotropic agent - application of DSC, spectroscopy and microscopy in assessment of the type of interaction

Oberoi, Lalit M
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1083685415

Abstract Details

2004, Master of Science in Pharmaceutical Sciences, University of Toledo, Pharmaceutical Science.
The purpose of this study was to examine the nature of the solid-state interaction between ibuprofen and nicotinamide and determine the solubility enhancement achieved by using nicotinamide as a hydrotropic agent and develop a suitable efficacious formulation. Ibuprofen-nicotinamide binary mixtures were prepared by solvent evaporation method. DSC studies suggested complex formation between ibuprofen and nicotinamide with 1:1 stoichiometry in solid state. UV-Visible spectroscopy suggested that the interaction was weak. Disappearance of the broad hydrogen bonding peak in the FTIR spectrum for the complex predicted greater solubility for the complex. Proton NMR studies ruled out the possibility of any chemical interaction between the two compounds. PXRD and microscopic studies showed that the crystallinity of the complex was remarkably reduced. All the studies predicted greater solubility for ibuprofen in complexed form. The HPLC studies showed that solubility was enhanced 62 times in the suspension when the concentration of nicotinamide was 13.3 mg/mL.
Kenneth Alexander (Advisor)
125 p.
Health Sciences, Pharmacy
ibuprofen; nicotinamide; hydrotropy; spectroscopic; solubility enhancement

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Citations

  • Oberoi, L. M. (2004). Formulation of a fast-acting ibuprofen suspension by using nicotinamide as hydrotropic agent - application of DSC, spectroscopy and microscopy in assessment of the type of interaction [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1083685415

    APA Style (7th edition)

  • Oberoi, Lalit. Formulation of a fast-acting ibuprofen suspension by using nicotinamide as hydrotropic agent - application of DSC, spectroscopy and microscopy in assessment of the type of interaction. 2004. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1083685415.

    MLA Style (8th edition)

  • Oberoi, Lalit. "Formulation of a fast-acting ibuprofen suspension by using nicotinamide as hydrotropic agent - application of DSC, spectroscopy and microscopy in assessment of the type of interaction." Master's thesis, University of Toledo, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1083685415

    Chicago Manual of Style (17th edition)

toledo1083685415
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© 2004, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.