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The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors

Ronquillo, Yasmyne Castillo
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420

Abstract Details

2009, Master of Science, University of Toledo, Biology (Cell-Molecular Biology).
Tumors of the salivary glands are some of the most complex tumors known. Although the progression from a benign salivary gland tumor to a malignancy has been documented in the literature, this process is not well understood. Pleomorphic adenoma (PA) is a type of benign tumor known clinically and histopathologically to transform into a malignant form in both the salivary glands and lacrimal glands. Pleomorphic Adenoma Gene 1 (PLAG1) overexpression is the initial abnormality found in PA. The molecular changes in the progression from PA to early stages of malignancy have not been fully elucidated. However, the inactivation of tumor suppressor genes and the activation of oncogenes and proto-oncogenes appear to be involved in the early transition phase to malignancy. The inactivation of p53, the loss of DCC, p16 and the activation of the oncogenes p21, c-myc and c-ras have been documented in cell culture, animal studies and human salivary gland tumors. In the intermediate and late stage of the transformation of PA to a malignant carcinoma ex pleomorphic adenoma (CXPA), the cell cycle genes CDC25A, erb-2, cdk-4, E2F-1, Bub-1, STAT3 are involved. The receptors PDGFR, Her-2/neu, androgen receptor and BRST-2 receptor are upregulated in some malignant tumors of the salivary gland. A model for the malignant transformation of pleomorphic adenoma to carcinoma is proposed. This model is analogous to the multi-stage tumorigenesis model of colon cancer. The studies of salivary gland tumors can serve as templates for the study of the malignant transformation in lacrimal gland tumors, the literature of which is sparse.
Patricia Komuniecki, Dr. (Advisor)
Song-Tau Liu, Dr. (Committee Member)
Lirim Shemshedini, Dr. (Committee Member)
William Taylor, Dr. (Committee Member)
77 p.
Biology
Malignant transformation; salivary gland tumors; Pleomorphic adenoma Gene

Recommended Citations

Citations

  • Ronquillo, Y. C. (2009). The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420

    APA Style (7th edition)

  • Ronquillo, Yasmyne. The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors. 2009. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420.

    MLA Style (8th edition)

  • Ronquillo, Yasmyne. "The Mechanisms of Malignant Transformation in Benign Salivary Gland Tumors." Master's thesis, University of Toledo, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1250207420

    Chicago Manual of Style (17th edition)

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© 2009, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.