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The Effects of the Transcription Factor SRY1 on Left Ventricular Function

Armour, Sylvia
http://rave.ohiolink.edu/etdc/view?acc_num=akron1208193131

Abstract Details

2008, Master of Science, University of Akron, Biology.
It has been found that there are gender differences in the cardiovascular system that result with the male gender being at an advantage after a myocardial infarction (MI) (Norton et al, 2008). In an effort to understand the cause of these differences, researchers have investigated the effects of testosterone on the heart, but have not been able to come to a consensus. Sry, which is also known as the testis determining factor, has been shown to be expressed in the adult Rattus norvegicus heart (Ely et al, 2007), and could be responsible along with testosterone to account for the differences. The aim of the current study was to investigate the effects of the transcription factor Sry1 on left ventricular function. Left ventricular function was evaluated by performing heart isolation procedures 21 days post Sry1 administration. Coronary flow, heart weight, diastolic, and systolic pressures were evaluated. Our lab had previously shown that Sry transcripts are co-expressed with tyrosine hydroxylase in the heart (Milsted et al, 2004), and so we hypothesized that Sry1 could possibly affect heart function by a catecholamine and a testosterone mechanism. Plasma testosterone and heart norepinephrine levels were measured in order to determine a possible mechanism. The administration of exogenous Sry1 into the heart resulted in the castrate+Sry1 group having increased left ventricular systolic (p<0.001), and diastolic (p<0.001) pressures compared to the castrate group. The sham+Sry1 had significantly higher diastolic pressures than the castrate group (p=0.009). Diastolic and systolic contractility and relaxation, heart weight, and coronary flow, were similar for all treatment groups. There was a trend of a positive correlation between increased levels of norepinephrine in Sry1 treated animals when compared to controls. The cast+Sry1 group had 14% more heart norepinephrine content than the cast group, and the sham+Sry1 group had 17% more NE than the sham group. Our results suggest that the transcription factor Sry plays a role in cardiovascular function through a catecholamine mechanism.
Daniel Ely, Ph.D. (Advisor)
48 p.
Biology
Sry; heart

Recommended Citations

Citations

  • Armour, S. (2008). The Effects of the Transcription Factor SRY1 on Left Ventricular Function [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1208193131

    APA Style (7th edition)

  • Armour, Sylvia. The Effects of the Transcription Factor SRY1 on Left Ventricular Function. 2008. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1208193131.

    MLA Style (8th edition)

  • Armour, Sylvia. "The Effects of the Transcription Factor SRY1 on Left Ventricular Function." Master's thesis, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1208193131

    Chicago Manual of Style (17th edition)

akron1208193131
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© 2008, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.