Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


akron1217301493.pdf (8.21 MB)

ETD Abstract Container

Abstract Header

The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes

Hindi, Khadijah M.
http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

Abstract Details

2008, Doctor of Philosophy, University of Akron, Chemistry.
The formation of the first transition metal complexes of N-heterocyclic carbenes (NHCs) by ændash;fele and Wanzlick in 1968 and the discovery of the first stable and isolable free carbenes by Arduengo in 1991 fostered the growth of this fundamental area of chemical research. Currently, NHCs and their metal complexes are intensely studied for applications such as catalysis and most recently their pharmaceutical properties. The latter has shown promising results and thus will be the primary focus of this dissertation. In general, this dissertation will provide a description of the synthesis and antimicrobial properties of a novel class of silver NHC complexes derived from 4,5-dichloroimidazole and a comparison of its enhanced stability in relation to other silver NHCs synthesized in our laboratory. Chapter 1, the introduction, provides an overview of the medicinal applications of various metal NHC complexes including silver, gold, ruthenium, rhodium, and palladium. This follows a necessary discussion of the known properties of the metals including antimicrobial, antitumor, toxicity, resistance and proposed mechanisms of action. Chapter 2, discusses the synthesis, properties, and antimicrobial activity of a silver(I) acetate NHC complex derived from 4,5-dichloroimidazole with enhanced stability. This discussion is coupled with a comparison to two other structurally similar complexes lacking similar enhanced stability properties. Chapter 3 will provide a detailed account of the stability of the silver NHC complex reported in chapter 2 in various forms of aqueous media formulations including D2O, 0.9% NaCl/D2O, and broth/D2O mixtures utilizing NMR spectral techniques. Chapter 4 will focus on the synthesis of a silver NHC complex bearing a lipophilic substituent, its incorporation into L-tyrosine polyphosphate (LTP) nanospheres, and its in vivo antimicrobial efficacy when delivered to mice inoculated with Pseudomonas aeruginosa. Chapter 5 is devoted to the synthesis and characterization of imidazolium salt precursors functionalized with a variety of substituents and their corresponding silver NHC complexes. In chapter 6, the potential use of several different silver NHC complexes as a treatment of Onychomycosis, a common fungal infection of the nails is explored. The in vitro antifungal activity and penetration potential is reported.
Wiley Youngs (Advisor)
Claire Tessier (Advisor)
297 p.
Chemistry
NMR; nanospheres; ¿¿¿¿¿; broth/D2O; SILVER; NHCs; COMPLEXES

Recommended Citations

Citations

  • Hindi, K. M. (2008). The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

    APA Style (7th edition)

  • Hindi, Khadijah. The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes. 2008. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493.

    MLA Style (8th edition)

  • Hindi, Khadijah. "The Medicinal Applications and Stability Evaluation of Silver (I) Carbene Complexes." Doctoral dissertation, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1217301493

    Chicago Manual of Style (17th edition)

akron1217301493
1,240
© 2008, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.