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Synthesis and Functionality of Polymeric Diazeniumdiolates in the Use and Control of Nitric Oxide Release for Severe Medicinal Atherosclerotic Plaque Applications and Human Papillomavirus Treatment

Elam, Chanda LaVortriette
http://rave.ohiolink.edu/etdc/view?acc_num=akron1218691731

Abstract Details

2008, Doctor of Philosophy, University of Akron, Chemistry.
Current research utilizing nitric oxide for its wound healing properties has propelled researchers to expand current applications. One application is the use of polymeric diazeniumdiolates to increase nitric oxide’s vasodilation properties, namely in the area of atherosclerotic plaque. Earlier commercial use of coated stents in the pharmaceutical arena for arterial blockage showed great promise with the exception of remission of plaque buildup within the stent. The same procedure has been applied to relieve thrombogenic plaque, which has lead to restenosis (re-narrowing) of the coronary artery due to trauma at the site of the stent or coiling. The body’s natural instinct is to cause clotting (thrombosis), thus restenosis, at that site. Instead of using polymeric diazeniumdiolates for stent coating and long-term usage, the polymeric diazeniumdiolate could be used to alleviate the body’s response to restenosis as well as increase the release time of nitric oxide from several days to weeks or longer. The body will naturally process the diamine to its biodegradable by-products and thereby remove them as waste from the body. Studies have shown that nitric oxide-producing PEG derivatives in conjunction with hydrogels have been able to release nitric oxide over a period of a couple of days with a short release time. However, flexibility in the release profile will prove useful in the treatment of atherosclerotic thrombosis and restenosis. At the same time these diazeniumdiolates were tested for applicable use for the treatment of the high-risk human papillomavirus (HPV) types 16 and types 18. Previous research shows that nitric oxide has been effective in the treatment of low-risk HPV, namely plantar warts and the like. It is hypothesized that if the virus is responsive to nitric oxide in its cutaneous, benign growth stage then it is possible that the mucosal, malignant growth is susceptible to nitric oxide treatment. A study using HeLa (wild type, HPV type 18), C33A (mutant, HPV negative) and CaSki (wild type, HPV type 16) cervical cancer cells has been used to determine the effectiveness of nitric oxide on high-risk HPV and determine the genetic process effected in the treatment. Bioavailability testing was performed to determine future drug therapy for nitric oxide producing compounds in the treatment of HPV-induced cervical cancer.
Daniel J. Smith, PhD (Advisor)
151 p.
Chemistry
nitric oxide; diazeniumdiolate; biomaterials; human papillomavirus

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Citations

  • Elam, C. L. (2008). Synthesis and Functionality of Polymeric Diazeniumdiolates in the Use and Control of Nitric Oxide Release for Severe Medicinal Atherosclerotic Plaque Applications and Human Papillomavirus Treatment [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1218691731

    APA Style (7th edition)

  • Elam, Chanda. Synthesis and Functionality of Polymeric Diazeniumdiolates in the Use and Control of Nitric Oxide Release for Severe Medicinal Atherosclerotic Plaque Applications and Human Papillomavirus Treatment. 2008. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1218691731.

    MLA Style (8th edition)

  • Elam, Chanda. "Synthesis and Functionality of Polymeric Diazeniumdiolates in the Use and Control of Nitric Oxide Release for Severe Medicinal Atherosclerotic Plaque Applications and Human Papillomavirus Treatment." Doctoral dissertation, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1218691731

    Chicago Manual of Style (17th edition)

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© 2008, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.