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Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms

Adya, Vandana

Abstract Details

2008, Master of Science in Engineering, University of Akron, Biomedical Engineering.
The main purpose of this study is to explore the potential of optically active molecules in conjunction with single pixel detectors and polarimetric techniques for early detection of tissue pathologies. Optical polarimetry can provide invaluable biological information based on molecular composition of the medium, structure, geometry, and metabolism. The preclinical phantom used was a rectangular plexiglass container and the experiments were carried out under backscattering detection geometry. A NIRVANA (Newfocus Inc., Model 2007, Santa Clara, CA, USA) auto balance detector was employed throughout the study. Initial readings were taken with water, and then aqueous solution of optically active molecules was added into it. The readings were obtained for the two states of polarization of light, parallel and perpendicular polarization. The signal-to-noise ratio and detective quantum efficiency (DQE) were calculated. The outcome of this study indicated an increase of the backscattered detected signal, signal-to-noise ratio, and the DQE of the imaging system, with increase in the concentration of optically active contrast agents. The results obtained were validated by performing linear regression analysis and paired t-test. The statistical analysis indicated increase in backscattered detected signal, signal to noise ratio, DQE and significant difference between the two states of polarization. This increase in the backscattered signal due to difference in the refractive index between the background and the object, leads to an increased contrast image that would assist in the early detection of tumor, other tissue pathologies, and biological structures.
George Giakos (Advisor)
93 p.

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Citations

  • Adya, V. (2008). Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620

    APA Style (7th edition)

  • Adya, Vandana. Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms. 2008. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620.

    MLA Style (8th edition)

  • Adya, Vandana. "Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms." Master's thesis, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620

    Chicago Manual of Style (17th edition)