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A Principal Component Regression Analysis for Detection of the Onset of Nocturnal Hypoglycemia in Type 1 Diabetic Patients

Zuzarte, Ian Jeromino
http://rave.ohiolink.edu/etdc/view?acc_num=akron1226955083

Abstract Details

2008, Master of Science in Engineering, University of Akron, Biomedical Engineering.
Nocturnal hypoglycemia has been a factor in the sudden deaths of diabetic patients. Episodes of hypoglycemia in adults and children with Type 1 diabetes induce abnormalities in cardiac repolarization, including lengthening of the QT interval, QT dispersion and changes in T wave morphology. In certain circumstances, abnormally low blood glucose could be responsible for the development of a fatal cardiac arrhythmia. In this study a monitoring and alarm system was designed for detection of the onset of spontaneous nocturnal hypoglycemia through monitoring of the electrocardiogram of 24 Type I diabetic patients. It utilized the principal component regression analysis to interpret the variability of the RT interval of the ECG. It also monitored changes in the T-wave amplitude and raised alarms if abnormalities corresponding to hypoglycemia are detected. The top performance of the system was 91.60%, 100% and 85.71% for accuracy, sensitivity and specificity respectively, which were statistically comparable to those obtained for the system using the tangent method. This study supports the proposition that a relationship exists between cardiac function and abnormally low blood glucose.
Dale Mugler, PhD (Advisor)
93 p.
Biomedical Research; Engineering
Nocturnal hypoglycemia; Type 1 diabetes; Prolonged QTc; T-wave; Principal Component Analysis; Principal Component Regression

Recommended Citations

Citations

  • Zuzarte, I. J. (2008). A Principal Component Regression Analysis for Detection of the Onset of Nocturnal Hypoglycemia in Type 1 Diabetic Patients [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1226955083

    APA Style (7th edition)

  • Zuzarte, Ian. A Principal Component Regression Analysis for Detection of the Onset of Nocturnal Hypoglycemia in Type 1 Diabetic Patients. 2008. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1226955083.

    MLA Style (8th edition)

  • Zuzarte, Ian. "A Principal Component Regression Analysis for Detection of the Onset of Nocturnal Hypoglycemia in Type 1 Diabetic Patients." Master's thesis, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1226955083

    Chicago Manual of Style (17th edition)

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© 2008, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.