Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


akron1227467806.pdf (706.68 KB)

ETD Abstract Container

Abstract Header

Microarray Data Analysis Tool (MAT)

Selvaraja, Sudarshan
http://rave.ohiolink.edu/etdc/view?acc_num=akron1227467806

Abstract Details

2008, Master of Science, University of Akron, Computer Science.
Microarray is a technology that has been widely used by the biologists to probe the presence of genes in a sample of DNA or RNA. Using the technology, the oligonucleotide probes can be massively parallel immobilized on a microarray chip. It allows the biologists to check the expression levels of thousands of genes together. This thesis develops a software system that includes a database repository to store different microarray datasets and a microarray data analysis tool for analyzing the stored data. The repository currently allows datasets of GenepixPro format to be deposited, although it can be expanded to include datasets of other formats. The user interface of the repository allows users conveniently upload data files and perform preferred data preprocessing and analysis. The analysis methods implemented includes the traditional k-nearest neighbor (kNN) methods and two new kNN methods developed in this study. Additional analysis methods can be added by future developers. The system was tested using a set of microRNA gene expression data. The design and implementation of the software tool are presented in the thesis along with the testing results from the microRNA dataset. The results indicate that the new weighted kNN method proposed in this study outperforms the traditional kNN method and the proposed mean method. We conclude that the system developed in the thesis effectively provides a structured microarray data repository, a flexible graphical user interface, and rational data mining methods.
Dr. Zhong-Hui Duan, PhD (Advisor)
Bioinformatics; Computer Science
MAT; Microarray; Data Mining; microRNA; kNN; Weighted kNN

Recommended Citations

Citations

  • Selvaraja, S. (2008). Microarray Data Analysis Tool (MAT) [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1227467806

    APA Style (7th edition)

  • Selvaraja, Sudarshan. Microarray Data Analysis Tool (MAT). 2008. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1227467806.

    MLA Style (8th edition)

  • Selvaraja, Sudarshan. "Microarray Data Analysis Tool (MAT)." Master's thesis, University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1227467806

    Chicago Manual of Style (17th edition)

akron1227467806
3,042
© 2008, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.