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Simulation of a Complete Cardiovascular Loop: Development of a Simulink Based Pressure-Flow Model to Obtain the Origin of the Electrical Impedance Cardiogram

Trivedi, Dyuti Kishorbhai
http://rave.ohiolink.edu/etdc/view?acc_num=akron1232729044

Abstract Details

2009, Master of Science in Engineering, University of Akron, Biomedical Engineering.
Impedance cardiography is a non-invasive measurement method to determine cardiac output and stroke volume. The reason behind this method’s lack of popularity for clinical purposes is a dearth of understanding about the factors contributing to the origin of impedance cardiogram. Variations in instantaneous volumes form the thoracic cavity contribute to the change in impedance curve, and in the past several simulations were performed based on this concept. In the present study, a lumped parameter model of a multi-loop circulatory system was developed using Simulink®. The model outputs were flow/pressure waveforms, which exhibit a similarity with physiological curves. The impedance cardiogram was determined by a first-order derivative of a weighted sum of instantaneous thoracic volumes. With correctly adjusted lumped volumes, it was assumed that the signal obtained from the model would be analogous to the dz/dt curve. The volumes were adjusted through variable gain amplifiers incorporated in the model and adjusted by the Simulink Response Optimization Toolbox ® routine of Matlab®. The optimization process tuned the gains to minimize the differences between the simulated and reference waveform. This process was carried out for different combinations of the volumes to obtain the most morphologically similar waveform. The results suggest that the impedance cardiogram waveform is related to volume changes in the thoracic vena cava, abdominal vena cava and ascending aorta.
Bruce C. Taylor, PhD (Advisor)
Biomedical Research
Impedance Cardiogram; Cardiovascular Modeling; Simulink; Mathematical modeling of Cardiovascular system; Simulink Response Optimization

Recommended Citations

Citations

  • Trivedi, D. K. (2009). Simulation of a Complete Cardiovascular Loop: Development of a Simulink Based Pressure-Flow Model to Obtain the Origin of the Electrical Impedance Cardiogram [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1232729044

    APA Style (7th edition)

  • Trivedi, Dyuti. Simulation of a Complete Cardiovascular Loop: Development of a Simulink Based Pressure-Flow Model to Obtain the Origin of the Electrical Impedance Cardiogram. 2009. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1232729044.

    MLA Style (8th edition)

  • Trivedi, Dyuti. "Simulation of a Complete Cardiovascular Loop: Development of a Simulink Based Pressure-Flow Model to Obtain the Origin of the Electrical Impedance Cardiogram." Master's thesis, University of Akron, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1232729044

    Chicago Manual of Style (17th edition)

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© 2009, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.