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Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels

Lu, Xing
http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060

Abstract Details

2013, Master of Science, University of Akron, Polymer Engineering.
Copolymers of hydrophilic N,N-dimethylacrylamide (DMA) and hydrophobic 2-(N-ethylperfluorooctane sulfonamido) ethyl methacrylate (FOSM) was synthesized by free radical polymerization with FOSM quantitatively incorporated ranging in composition from 0% to 30% as demonstrated by 1H-NMR. These polymers can form hydrogels in an aqueous environment through hydrophobic association of the FOSM moieties which act as physical cross-links. Thermal properties, water content, drug uptake and release behavior was investigated. Tg and water content decreased with the increasing incorporation of FOSM. Cyclosporine A (CsA), an immunosuppressant agent, was selected as the model drug substance and loaded into the hydrogels. CsA showed higher affinity for the polymer phase and the preference increased with increasing FOSM content. A first-order release profile was observed for hydrogels presoaked in aqueous solution. Release exponent (n=0.5) suggested the drug release mechanism was Fickian. A pseudo zero-order release behavior was observed for hydrogels presoaked in DMSO/water mixture solution. Release exponent (n=0.7) implied an anomalous mechanism. A combined model was proposed assuming simultaneous Fickian diffusion from hydrophilic matrix and diffusion from FOSM nanodomains as nano drug reservoirs for kinetics and mechanism analysis. In both cases, drug transport rate attenuated with increasing hydrophobic modification suggesting drug release behavior can be tuned by FOSM content. Drug diffusion coefficients were obtained by model fitting based on early-time, Etters approximation and combined model assumption. The duration of CsA release within therapeutic window can be extended to 15 days from these hydrogels. These thermo-processible hydrogels have potential to be used as controlled ocular drug delivery devices.
Robert Weiss, Dr. (Advisor)
Alamgir Karim, Dr. (Committee Member)
Kevin Cavicchi, Dr. (Committee Member)
103 p.
Materials Science; Polymers
Drug delivery; Hydrogel; Hydrophobical Modification

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Citations

  • Lu, X. (2013). Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060

    APA Style (7th edition)

  • Lu, Xing. Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels. 2013. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060.

    MLA Style (8th edition)

  • Lu, Xing. "Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels." Master's thesis, University of Akron, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.