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Polymeric Micellar Network Derived from the Polymerization of Bicontiuous Microemulsion for Oral Drug Delivery Application

Sodunke, Oluyomi
http://rave.ohiolink.edu/etdc/view?acc_num=akron1429738431

Abstract Details

2015, Master of Science in Engineering, University of Akron, Chemical Engineering.
Over the last decade, the growth of nanosized or nanometric size drug delivery systems has increased the challenge for innovations enabling realistic progress to achieve orally administered chemotherapeutic drugs. Polymeric biomaterial drug delivery systems pose a great avenue for the oral delivery of chemotherapeutic drugs. The polymeric biomaterial possesses porous networks composed of a hydrophobic core and a hydrophilic shell. The hydrophobic core can be used to encapsulate drugs and achieve characteristics that can protect anticancer drugs from degradation by enzymes and acid pH environments, reduce drug toxicity, prolong the release of the drug and enhance the drugs solubility. Microemulsions are thermodynamically stable isotropic and transparent dispersions of two normally immiscible fluids stabilized by surfactants. Microemulsion has been widely used in several applications including oil recovery, detergent and bioreactors. The polymerization of bicontinuous microemulsions is a one-pot system to make porous polymeric materials also known as hydrogels which is studied here as a potential controlled drug delivery application. In this research, a pH- responsive polymerized gel or hydrogel was made from bicontinuous microemulsion to be used as an oral drug delivery system. The bicontinuous microemulsion consists of comonomer 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA), methyl methacrylate (MMA) monomer, and a Pluronic® triblock copolymer surfactant with characteristics of poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) (PEO-PPO-PEO). All the components in the hydrogel are FDA approved for oral drug delivery making it a biocompatible hydrogel. A model drug is loaded in the polymer network of the hydrogel and an attempt is made to correlate the chemistry and structure of the hydrogel to its reaction in different pH environments and observing the release of the model drug.
Harry Michael Cheung, Dr. (Advisor)
Chelsea Monty, Dr. (Committee Member)
Gang Cheng, Dr. (Committee Member)
182 p.
Biomedical Research; Chemical Engineering; Chemistry; Medicine

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Citations

  • Sodunke, O. (2015). Polymeric Micellar Network Derived from the Polymerization of Bicontiuous Microemulsion for Oral Drug Delivery Application [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1429738431

    APA Style (7th edition)

  • Sodunke, Oluyomi. Polymeric Micellar Network Derived from the Polymerization of Bicontiuous Microemulsion for Oral Drug Delivery Application. 2015. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1429738431.

    MLA Style (8th edition)

  • Sodunke, Oluyomi. "Polymeric Micellar Network Derived from the Polymerization of Bicontiuous Microemulsion for Oral Drug Delivery Application." Master's thesis, University of Akron, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1429738431

    Chicago Manual of Style (17th edition)

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