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Development of Compact Multimodal Optical Imaging and Medical Assessment Systems

Quang, Tri T
http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192

Abstract Details

2015, Master of Science in Engineering, University of Akron, Biomedical Engineering.
Development of medical devices in a small size, lightweight and low cost design is attracting growing attentions in healthcare. Compact, portable and easy to use systems that can solve a specific medical or health related problem and also offer customization and integration abilities to perform multi-functional features are appealing options to clinicians. In the thesis, two proposed systems for multimodal optical imaging and medical assessment are presented. The first part describes a novel mobile eye tracking based traumatic brain injury assessment system that was developed to detect traumatic brain injuries (TBIs). Integrated visual tracking and visuomotor tests were developed to assess TBI quickly and conveniently. The system can be operated in mobile devices such as tablets and cell phones and enables videooculographic and visuomotor assessment of patients based on a target-oriented visual tracking-touching synchronization. Two simulation tests were utilized to test system performance in detection of impaired eye movement. Statistically significant differences between the pathological simulation and normal cases were found in the concentration test (P<.0001), the horizontal (P=.0005) and circular movement tests (P=.0013) with a statistical power of 80.5%. 100% touch success and shorter time in performing the visuomotor test were obtained in normal cases. The second part describes the development of a Fluorescence Imaging Topology Scanning (FITS) system. Clinically, conventional imaging modalities such as positron emission tomography, x-ray computed tomography and fluorescence molecular tomography can provide useful data to clinicians. However, these tomographic imaging modalities are not optimized for intraoperative settings due to the slow scan time and the lack of real time update which is crucial for guiding surgery. The FITS system can offer color reflectance imaging, fluorescence imaging and surface topology scanning capabilities for three-dimensional multimodal imaging. In this study, system characterization, ex vivo image-guided surgeries in chicken and in vivo multimodal imaging of sentinel lymph nodes (SLNs) in mice using FITS and PET/CT were conducted to validate the capabilities of the system in providing multimodal imaging for surgery. The prototype offers a sub-millimeter lateral resolution, a sub-millimeter depth resolution for topology and 10nM fluorescence detection sensitivity. Fluorescence labeled targets were successfully identified and highlighted. Lymph vessels (diameter < 0.3mm) and the SLNs were imaged (average SBR of the lymph node = 6.09 ± 0.6). The system is compact and portable, and thus suitable for deployment in the operating room. These systems have demonstrated great potential in supporting clinical decision making and guiding medical assessments.
Yang Liu (Advisor)
Brian Davis (Committee Member)
Bing Yu (Committee Member)
50 p.
Biomedical Engineering
medical device; TBI; FITS

Recommended Citations

Citations

  • Quang, T. T. (2015). Development of Compact Multimodal Optical Imaging and Medical Assessment Systems [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192

    APA Style (7th edition)

  • Quang, Tri. Development of Compact Multimodal Optical Imaging and Medical Assessment Systems. 2015. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192.

    MLA Style (8th edition)

  • Quang, Tri. "Development of Compact Multimodal Optical Imaging and Medical Assessment Systems." Master's thesis, University of Akron, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1452533192

    Chicago Manual of Style (17th edition)

akron1452533192
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© 2015, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.