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Synthesis and Characterization of Photoresponsive Polyesters for Improved Mechanical Properties and Erosion Properties

Li, Tianyu
http://rave.ohiolink.edu/etdc/view?acc_num=akron1460381096

Abstract Details

2016, Master of Science, University of Akron, Polymer Science.
Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable copolymer with a tailored degradation rate, which has been widely used in biomaterials,such as screws, sutures and as the matrix of drug release devices. However, PLGA has slow a hydrolytic degradation rate and relatively low modulus, which might hamper its applications.1,2 In this study, photo-responsive molecule 2-(4-(2-hydroxyacetyl) phenoxy)acetic acid was introduced into PLGA, which can provide spatial and temporal control of degradation under UV irradiation. The rigid structure of the photo-responsive molecule can be utilized to enhance the thermal properties and mechanical properties of PLGA. On the other hand, the photodegradable nature of the polymer may enable the degradation product to be recycled into useful products. Another work involves 2-hydroxy-1-(4-(3-hydroxypropoxy)phenyl)ethanone based photo-degradable copolymers for controlled drug release. In this work, the photo- responsive molecule was incorporated into polymers. Surface erosion of polymeric matrixes is advantageous for controlled drug delivery.3 The erosion property of this polymer will be tested by ellipsometry.
Abraham Joy (Advisor)
Yu Zhu (Committee Member)
Polymers

Recommended Citations

Citations

  • Li, T. (2016). Synthesis and Characterization of Photoresponsive Polyesters for Improved Mechanical Properties and Erosion Properties [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460381096

    APA Style (7th edition)

  • Li, Tianyu. Synthesis and Characterization of Photoresponsive Polyesters for Improved Mechanical Properties and Erosion Properties. 2016. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1460381096.

    MLA Style (8th edition)

  • Li, Tianyu. "Synthesis and Characterization of Photoresponsive Polyesters for Improved Mechanical Properties and Erosion Properties." Master's thesis, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460381096

    Chicago Manual of Style (17th edition)

akron1460381096
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This open access ETD is published by University of Akron and OhioLINK.