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XieY.the (final comments 2).pdf (5.15 MB)

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Synthesis And Characterization of Mannose-grafted Peptide-Like Polyesters

Xie, Yixuan
http://orcid.org/0000-0002-4284-969X
http://rave.ohiolink.edu/etdc/view?acc_num=akron1460383230

Abstract Details

2016, Master of Science, University of Akron, Polymer Science.
Glycoproteins play significant roles in many physiological as well as pathological cell functions and they are potential for the development of therapeutics, diagnostics, and vaccines. However, the function of glycoproteins is not fully understood due to the challenge to obtain them in a homogeneous form. Therefore, different types of synthetic analogues of glycoprotein have been prepared in literature to mimic the properties of natural glycoproteins. In this work, mannose-grafted copolyesters were designed as polymeric analogues of glycoprotein, which contain a peptide-like polyester backbone and mannose-based polyacrylate side chain. The graft copolymers were then prepared by “grafting to”, “grafting through” and “grafting from” method. The number of carbohydrates in the polymer was determined by sulfuric acid assay. The interaction between these mannose-grafted polyesters and Concanavalin A (Con A) was then studied by turbidimetry binding assay.
Abraham Joy (Advisor)
Yu Zhu (Committee Member)
98 p.
Polymer Chemistry; Polymers
Glycoprotein; Polymer; Glycopolymer

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Citations

  • Xie, Y. (2016). Synthesis And Characterization of Mannose-grafted Peptide-Like Polyesters [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460383230

    APA Style (7th edition)

  • Xie, Yixuan. Synthesis And Characterization of Mannose-grafted Peptide-Like Polyesters. 2016. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1460383230.

    MLA Style (8th edition)

  • Xie, Yixuan. "Synthesis And Characterization of Mannose-grafted Peptide-Like Polyesters." Master's thesis, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460383230

    Chicago Manual of Style (17th edition)

akron1460383230
176
© 2016, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.