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Amorphous Calcium Phosphate Composites of a Phenylalanine-based Poly(ester urea) Poly(1-PHE-6)

Seifert, Gabrielle Victoria
http://rave.ohiolink.edu/etdc/view?acc_num=akron1460388339

Abstract Details

2016, Master of Science, University of Akron, Polymer Science.
Critical size bone defects are large defects that do not spontaneously heal over time and result in permanent non-union of the bone. These abnormalities can result from traumas, surgeries, and diseases. Surgical methods used to treat these defects include natural (autografts and allografts) and synthetic bone grafts. Autografts draw advantages from diminished immune response but suffer from complications during implantation as well as pain and cosmetic defects during removal. Allograft complications include rejection and infection. Infection can be minimized by sterile processing techniques, but this frequently leads to diminished mechanical properties post-processing. As a consequence of these limitations, synthetic bone grafts have drawn significant interest. Synthetic bone grafts include biodegradable polymers, metals, and ceramics. For example, poly(caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are biodegradable polymers used widely for medical applications. These materials can be molded into any desired shape; however, they are unsuitable for load-bearing applications as a consequence of their poor mechanical properties post-processing. Bioceramics, such as amorphous calcium phosphate (ACP), benefit from their osteoconductive behavior but are too brittle for load-bearing applications. Combining the biodegradable polymers with bioceramics have shown increased mechanical properties in the composites. The goal of this study was to examine the resulting mechanical properties of combining an L-phenylalanine-based poly(ester urea) (PEU) with various amount of ACP. We hypothesize that adding ACP to the polymer will lead to enhanced mechanical properties compared to the pure polymer.
Matthew Becker, Dr. (Advisor)
Abraham Joy, Dr. (Committee Member)
67 p.
Polymers
PEU; amorphous calcium phosphate; critical size defect; biodegradable polymer; bioceramic; composite; modulus

Recommended Citations

Citations

  • Seifert, G. V. (2016). Amorphous Calcium Phosphate Composites of a Phenylalanine-based Poly(ester urea) Poly(1-PHE-6) [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460388339

    APA Style (7th edition)

  • Seifert, Gabrielle. Amorphous Calcium Phosphate Composites of a Phenylalanine-based Poly(ester urea) Poly(1-PHE-6). 2016. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1460388339.

    MLA Style (8th edition)

  • Seifert, Gabrielle. "Amorphous Calcium Phosphate Composites of a Phenylalanine-based Poly(ester urea) Poly(1-PHE-6)." Master's thesis, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460388339

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.