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A New Class of Biodegradable, Coacervate-Forming, Thermoresponsive Polyesters Based on N-Substituted Diols

Swanson, John Patrick
http://orcid.org/0000-0001-8820-7273
http://rave.ohiolink.edu/etdc/view?acc_num=akron1460414310

Abstract Details

2016, Doctor of Philosophy, University of Akron, Polymer Science.
Temperature-responsive smart materials, such as poly(N-isopropylacrylamide) (PNIPAM), undergo a reversible hydrophilicity change at a lower critical solution temperature (LCST) which makes them particularly attractive for biomedical applications such as targeted drug delivery. However, the nondegradable backbone of PAMs and many other thermoresponsive polymers ultimately limit their use for a number of applications. To date, few examples of thermoresponsive, biodegradable polymers exist. In looking to overcome these limitations, our lab has developed a library of thermoresponsive polyesters (TR-PEs) based on PAs and thermoresponsive elastin-like peptides (ELPs). A modular synthetic design allows for polyesterification of a variety of N-substituted diol monomers, yielding a library of TR-PEs. The LCST range can be tuned between 0-100 ºC, dependent on polymer structure and cosolutes, as evidenced by UV-vis, 1H NMR, and DLS. Additionally, the hydrophilic nature of TR-PEs prevents full dehydration above the LCST, resulting in the formation of polymer-rich coacervates capable of encapsulating hydrophobic small molecules and proteins. The degradable polyester backbone enables hydrolytic degradation over time. These features make TR-PEs attractive candidates for applications such as controlled drug release and degradable scaffolds.
Abraham Joy, Ph.D. (Advisor)
Matthew Becker, Ph.D. (Committee Chair)
Ali Dhinojwala, Ph.D. (Committee Member)
Mesfin Tsige, Ph.D. (Committee Member)
Nic Leipzig, Ph.D. (Committee Member)
240 p.
Chemistry; Organic Chemistry; Polymer Chemistry; Polymers
Biodegradation, stimuli-responsive polymers, biomaterials, polyesterification, thermoresponsive, coacervate

Recommended Citations

Citations

  • Swanson, J. P. (2016). A New Class of Biodegradable, Coacervate-Forming, Thermoresponsive Polyesters Based on N-Substituted Diols [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460414310

    APA Style (7th edition)

  • Swanson, John. A New Class of Biodegradable, Coacervate-Forming, Thermoresponsive Polyesters Based on N-Substituted Diols. 2016. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1460414310.

    MLA Style (8th edition)

  • Swanson, John. "A New Class of Biodegradable, Coacervate-Forming, Thermoresponsive Polyesters Based on N-Substituted Diols." Doctoral dissertation, University of Akron, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460414310

    Chicago Manual of Style (17th edition)

akron1460414310
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© 2016, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.