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Development of multi-functional polymeric biomaterials

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2017, Doctor of Philosophy, University of Akron, Chemical Engineering.
Antifouling materials that can effectively resist protein adsorption, cell adhesion and microorganism growth, are critical for a wide range of fundamental and industrial applications from ship coatings, biomedical implants, bioseparation, biosensors, and carriers for drug and gene delivery. However, only a few noufouling polymers (<0.3 ng/cm2 protein adsorption) are available. Development of new nonfouling materials and probing molecular structure-antifouling property relationship are extremely important but still challenging. We designed a series of hydrophilic antifouling polymers for both surface coatings and hydrogel fabrications. We synthesized poly (N-acryloylaminoethoxyethanol) (polyAAEE) brushes (Chapter II) with integration of three hydrophilic groups of amide, ethylene glycol and hydroxyl, via surface initiated atom transfer radical polymerization (SI-ATRP). PolyAAEE brushes demonstrated its excellent antifouling performance against protein adsorption from undiluted human blood plasma and serum, mammalian cells adhesion for 3 days. In order to control material-biomolecular interaction in real time, a smart stimuli-responsive poly(3-(1-(4-vinylbenzyl)-1H-benzo[d]imidazol-3-ium-3-yl) propane-1-sulfonate) (polyVBIPS) brushes (Chapter III) were developed which can be reversibly switched between antifouling and fouling state, acting as regenerative surface. The polyVBIPS brushes demonstrated its capability of surface regeneration in harsh medium of undiluted human plasma and serum and also bacterial medium. Inspired by the excellent antifouling properties of polyacrylamide-based polymer in the case of well controlled polymer brushes, multifunctional polyacrylamide based polymeric hydrogels were also developed for wide biomedical applications. A novel hybrid agar/polyacrylamide (Agar/PAM) DN hydrogels were designed with superior toughness, excellent antifouling (Chapter IV) and unique controllable swelling properties (Chapter V), which greatly improve the mechanical performance of hydrogels in both as-prepared states and swollen states while maintain its antifouling property. Furthermore, a new type of multi-stimuli-responsive hydrogel were also developed via the covalent incorporation of multi-stimuli-responsive mechanophore spiropyran (SP) in the hydrogel network via a novel design strategy (Chapter VI). The SP incorporated hydrogels demonstrated its unique dynamic color response under multiple external stimuli of heat, light and force, and mechanical strong and self-recovery properties, making it promising for potential applications for bioimaging and biosensing.
Jie Zheng (Advisor)
Bi-min Zhang Newby (Committee Member)
Bryan Vogt (Committee Member)
Lingyun Liu (Committee Member)
Shing-Chung Wong (Committee Member)
215 p.

Recommended Citations

Citations

  • Chen, H. (2017). Development of multi-functional polymeric biomaterials [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1490706379312092

    APA Style (7th edition)

  • Chen, Hong. Development of multi-functional polymeric biomaterials. 2017. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1490706379312092.

    MLA Style (8th edition)

  • Chen, Hong. "Development of multi-functional polymeric biomaterials." Doctoral dissertation, University of Akron, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1490706379312092

    Chicago Manual of Style (17th edition)