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Bioengineered Three-dimensional Lung Airway Models to Study Exogenous Surfactant Delivery

Copploe, Antonio
http://rave.ohiolink.edu/etdc/view?acc_num=akron1505482360585247

Abstract Details

2017, Master of Science, University of Akron, Biomedical Engineering.
Delivery of therapeutic fluids such as surfactant solutions into lungs is a major strategy to treat various respiratory disorders. Instilled solutions form liquid plugs in lung airways. The plugs propagate downstream in airways by inspired air or forced ventilation, continuously split at airway bifurcations to smaller daughter plugs and simultaneously lose mass from their trailing menisci, and eventually rupture. A uniform distribution of the instilled liquid in lung airways is expected to increase the treatments success. The uniformity of distribution of instilled liquid in the lungs greatly depends on the splitting of liquid plugs between daughter airways, especially in the first few generations of airways from which airways of different lobes of lungs emerge. To mechanistically understand the liquid plug splitting process, we develop a novel bioengineering approach to computationally design three-dimensional bifurcating airway models using morphometric data of human lungs, fabricate seamless physical models using additive manufacturing, and examine effects of geometry of airways, fluid properties, and flow characteristics on liquid plug splitting. We find that the orientation of bifurcating airways has a major effect on the splitting of liquid plugs between daughter airways and discuss the role of various forces including inertia, gravity, and surface tension using several dimensionless groups. This work provides a fundamental understanding toward developing delivery strategies for uniform distribution of therapeutic fluids in the lungs.
Hossein Tavana, PhD (Advisor)
Marnie Saunders, PhD (Committee Member)
Jae-Won Choi, PhD (Committee Member)
80 p.
Biomedical Engineering; Biomedical Research; Fluid Dynamics
fluid dynamics; fluid mechanics; surfactant delivery; bioengineering; bioengineered; three-dimensional; 3D; lung; airway; lung model; airway model; airway tree; bifurcation model; computational model; nRDS; infasurf; 3D printed model

Recommended Citations

Citations

  • Copploe, A. (2017). Bioengineered Three-dimensional Lung Airway Models to Study Exogenous Surfactant Delivery [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1505482360585247

    APA Style (7th edition)

  • Copploe, Antonio. Bioengineered Three-dimensional Lung Airway Models to Study Exogenous Surfactant Delivery. 2017. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1505482360585247.

    MLA Style (8th edition)

  • Copploe, Antonio. "Bioengineered Three-dimensional Lung Airway Models to Study Exogenous Surfactant Delivery." Master's thesis, University of Akron, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1505482360585247

    Chicago Manual of Style (17th edition)

akron1505482360585247
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© 2017, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.