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Electrospinning and Characterization of Polyisobutylene-based Thermoplastic Elastomeric Fiber Mats For Drug Release Application

Jindal, Aditya
http://rave.ohiolink.edu/etdc/view?acc_num=akron1512483246405986

Abstract Details

2018, Doctor of Philosophy, University of Akron, Chemical Engineering.
This dissertation presents the first report of local in vitro release of anti-inflammatory drugs, Zafirlukast and Aspirin, from an electrospun drug-eluting fiber mat made from novel non-commercialized, polyisobutylene-based thermoplastic elastomers. This drug-eluting fiber mat is a potential candidate for reducing the inflammatory response to silicone breast prosthesis. Linear poly(styrene-b-isobutylene-b-styrene) triblock copolymer (SIBS) is used in clinical practice as the drug-eluting polymeric coating on the TAXUSTM coronary stent for its excellent bioinertness and biostability. Over 6 million patients have benefited from this device, but due to the low permeability of the polymer, only ~10% of the encapsulated drug, Taxol, eluted from the coating in 330 days at 8.8 wt% loading. The next generation PIB-based thermoplastic elastomer (TPE), Arbomatrix with an arborescent polyisobutylene (PIB) core & poly(p-methyl styrene) (PMS) end blocks, was also shown to be bioinert in a rabbit model. Another novel PIB-based TPE, poly(alloocimene-b-isobutylene-b-alloocimene) (AIBA), which is a linear block copolymer developed by Puskas and coworkers, is also a suitable candidate for biomedical applications. Breast cancer is the most commonly diagnosed form of cancer and the second leading cause of cancer-related deaths in American women (246,660 new cases and 40,450 deaths in 2016). Approximately one-third of American women diagnosed with breast cancer undergo mastectomy, with approximately 70% of these women opting for silicone implant-based reconstruction. Capsular contracture is the most commonly reported problem with this approach. Capsular contracture is a distortion of an implant caused by tension resulting from the fibrous capsule forming around it due to an inflammatory response by the body against silicone rubber. Electrospinning is a versatile and unique process of creating fibers in the micron, sub-micron and nano diameter ranges with the help of electrostatic forces. Electrospinning has shown tremendous progress in applications in drug delivery in the past few years. This research work discusses the development of drug-eluting electrospun rubbery fiber mats for implant applications. The anti-inflammatory drugs, Zafirlukast (ZAF) and Aspirin (ASA) are used for embedding into the fibers of PIB-based TPEs, Arbomatrix and AIBA, and the release profiles are discussed. Local application of these mats has the potential to reduce capsular contracture, the major complication reported for silicone rubber breast prosthesis. Two different anti-inflammatory drugs were used in such a way, that the women, who are allergic to Aspirin, could take advantage of the other drug Zafirlukast. Also, it is theorized that the local release of the drugs from these electrospun fiber mats would not reach the toxic level to cause adverse effects on any organ inside the human body.
Judit Puskas (Advisor)
Teresa Cutright (Committee Member)
Darrell Reneker (Committee Member)
George Chase (Committee Member)
Jie Zheng (Committee Member)
266 p.
Biomedical Research; Chemical Engineering; Materials Science; Medicine; Morphology; Polymers; Textile Research
Electrospinning; zafirlukast; aspirin; drug release; polyisobutylene; thermoplastic elastomer; fibers; breast cancer; capsular contracture; polystyrene; polyalloocimene; block copolymer; microscopy; spectroscopy; tensile strength; diffusion; viscosity

Recommended Citations

Citations

  • Jindal, A. (2018). Electrospinning and Characterization of Polyisobutylene-based Thermoplastic Elastomeric Fiber Mats For Drug Release Application [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1512483246405986

    APA Style (7th edition)

  • Jindal, Aditya. Electrospinning and Characterization of Polyisobutylene-based Thermoplastic Elastomeric Fiber Mats For Drug Release Application. 2018. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1512483246405986.

    MLA Style (8th edition)

  • Jindal, Aditya. "Electrospinning and Characterization of Polyisobutylene-based Thermoplastic Elastomeric Fiber Mats For Drug Release Application." Doctoral dissertation, University of Akron, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1512483246405986

    Chicago Manual of Style (17th edition)

akron1512483246405986
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This open access ETD is published by University of Akron and OhioLINK.