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Thesis_Wan-Hua Lin.pdf (56.18 MB)

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Cellulose Aerogel Monoliths and Microparticles and Their Applications in Drug Delivery System

Lin, Wan-Hua
http://rave.ohiolink.edu/etdc/view?acc_num=akron1515433467041194

Abstract Details

2017, Master of Science in Polymer Engineering, University of Akron, Polymer Engineering.
Aerogels fabricated from cellulose are gaining great interests over the past decade. Researchers and scientists are developing new processes and seeking new applications from this long-standing material in human history. The review section provides an overview of the recent advances in process of cellulose aerogels fabrication, their properties, and applications, mainly focusing on the non-derivatizing cellulose. The cellulose aerogel fabrication process is divided into three methods, including those based on regeneration, mechanical means via MFC/NFCs, and bacterial means. In addition, the merits of several cellulose solvents applied in the regeneration process are analyzed. This study evaluates the potential of cellulose aerogel monoliths and microparticles in storage and release of drugs from the porous networks. A mixed solvent of ionic liquid and dimethylformamide expedites cellulose dissolution while ethanol regenerates cellulose in the form of gels. The gel microparticles of mean particle size 23–54 µm are obtained from oil-in-oil emulsions of cellulose solutions. The gels are dried under supercritical condition of CO2 to obtain aerogels. Aerogel crystallinity, porous network microstructures, bulk density, and surface area are determined. The aerogels show high specific surface area of 358±13 m2/g for the monolith and 426±12 m2/g for the microparticles and highest porosity of 99.0% for aerogels prepared from 1 wt% cellulose solution. Both monoliths and microparticles show similar microstructures with open pores and three-dimensional fibrillar networks. The results show that acetaminophen release from microparticles is considerably slower than from monoliths, thus endorsing the suitability of such materials as controlled drug release systems.
Sadhan C. Jana (Advisor)
Nicole Zacharia (Committee Member)
Younjin Min (Committee Member)
110 p.
Polymers
cellulose; aerogel; drug delivery

Recommended Citations

Citations

  • Lin, W.-H. (2017). Cellulose Aerogel Monoliths and Microparticles and Their Applications in Drug Delivery System [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515433467041194

    APA Style (7th edition)

  • Lin, Wan-Hua. Cellulose Aerogel Monoliths and Microparticles and Their Applications in Drug Delivery System. 2017. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1515433467041194.

    MLA Style (8th edition)

  • Lin, Wan-Hua. "Cellulose Aerogel Monoliths and Microparticles and Their Applications in Drug Delivery System." Master's thesis, University of Akron, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515433467041194

    Chicago Manual of Style (17th edition)

akron1515433467041194
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© 2017, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.