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Nikam.Shantanu_MS Thesis.pdf (1.92 MB)

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LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA)

Nikam, Shantanu P
http://orcid.org/0000-0002-4191-7187
http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122

Abstract Details

2018, Master of Science, University of Akron, Polymer Science.
Despite advances in aseptic surgical techniques and prophylactic antibiotics, the incidents of device associated infections are rising dramatically along with the increasing clinical demand for implanted devices. In this study we have attempted to tackle one type of device associated infection, the cardiac implantable electronic device (CIED) infection. The objective of this study was to design an antibiotic loaded pouch for CIEDs from novel valine based poly(ester urea) polymers for localized antibiotic delivery of antibiotic. Implanting CIED covered in this pouch would help prevent infections even at antibiotic dosage lower than currently employed. Additionally, it is expected to reduce side effects of systemic antibiotic administration and put minimum pressure on hepatic and renal functioning of patients. In this study, films with different antibiotic loading concentration and thickness were fabricated and analyzed for their antibiotic release profiles in vitro. Furthermore, antimicrobial susceptibility tests were also performed to confirm that antibiotic released from these groups retained its antimicrobial activity.
Matthew Becker (Advisor)
64 p.
Biomedical Engineering; Chemistry; Experiments; Materials Science; Organic Chemistry; Polymer Chemistry; Polymers
Infection, antibiotic, local drug delivery, poly ester urea, cardiac implantable electronic device,device infections

Recommended Citations

Citations

  • Nikam, S. P. (2018). LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA) [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122

    APA Style (7th edition)

  • Nikam, Shantanu. LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA) . 2018. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122.

    MLA Style (8th edition)

  • Nikam, Shantanu. "LOCALIZED ANTIBIOTIC DELIVERY VIA VALINE BASED POLY(ESTER UREA) ." Master's thesis, University of Akron, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522931095020122

    Chicago Manual of Style (17th edition)

akron1522931095020122
109
© 2018, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.