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JiayiYuDissertation.pdf (19.87 MB)

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Tunable Biodegradable Polymers for Regenerative Medicine

Yu, Jiayi
http://orcid.org/0000-0003-3697-9137
http://rave.ohiolink.edu/etdc/view?acc_num=akron1524821159786707

Abstract Details

2018, Doctor of Philosophy, University of Akron, Polymer Science.
Since the early 1960s, synthetic biodegradable polymers have been widely used in biomedical applications due to their large chemical diversity and the reproducible properties. However, the local acidification during degradation has shown to cause significant inflammation that can lead to device or implant failure. It is necessary to design new biodegradable polymer systems that do not cause local acidosis during degradation. To facilitate this requirement, Becker group has developed the amino acid-based poly(ester urea)s. These polymers are semi-crystalline. Their hydrolysis byproducts are non-toxic and can be self-buffered by the presence of the urea linkage at each repeat unit. In addition, there is a tremendous physical and chemical landscape that is available for exploration by using different natural amino acids with different pendant groups and different diols. This dissertation outlines our efforts to develop biodegradable polymers with tunable mechanical properties, degradation rates, and bioactivity. We varied the diol chain length (Chapter 3), branch density (Chapter 4), bioceramic contents (Chapter 5) in the poly(ester urea) system; cis/trans ratio (Chapter 6) in the biodegradable elastomer system and studied how these subtle structural differences would influence the mechanical properties and water uptake ability. Based on their tunable physical properties, these materials can be selected and used for various biomedical applications (Chapter 7).
Matthew L. Becker, Ph.D. (Advisor)
Bryan Vogt, Ph.D. (Committee Chair)
Yu Zhu, Ph.D. (Committee Member)
Amis J. Eric, Ph.D. (Committee Member)
Chrys Wesdemiotis, Ph.D. (Committee Member)
273 p.
Biomedical Engineering; Materials Science; Plastics; Polymer Chemistry; Polymers
biodegradable polymers; poly ester urea; diol chain length; branch density; composite; stereochemistry; mechanical property; biodegradation rate; application, processing; characterization; structure property relationship; amino acid; tunable property

Recommended Citations

Citations

  • Yu, J. (2018). Tunable Biodegradable Polymers for Regenerative Medicine [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524821159786707

    APA Style (7th edition)

  • Yu, Jiayi. Tunable Biodegradable Polymers for Regenerative Medicine. 2018. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1524821159786707.

    MLA Style (8th edition)

  • Yu, Jiayi. "Tunable Biodegradable Polymers for Regenerative Medicine." Doctoral dissertation, University of Akron, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524821159786707

    Chicago Manual of Style (17th edition)

akron1524821159786707
264
© 2018, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.