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Dissertation _Keyvan(Q) Amini Khoiy.pdf (9.3 MB)

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Biomechanical Characterization and Simulation of the Tricuspid Valve

Amini Khoiy, Keyvan
http://rave.ohiolink.edu/etdc/view?acc_num=akron1542651986497595

Abstract Details

, Doctor of Philosophy, University of Akron, Biomedical Engineering.
The tricuspid valve, which is located on the right side of the heart, prevents blood backflow from the right ventricle to the right atrium. Regurgitation in this valve occurs when its leaflets do not close normally. Tricuspid valve regurgitation is one of the most common tricuspid valve dysfunctions, often requiring valve repair or replacement. The long-term success rate of the repair surgeries has not been promising; in many cases, reoperations are required within a few years after the first surgery. A limiting factor in understanding the etiology of tricuspid valve repair failure is our lack of knowledge regarding tricuspid valve biomechanics. In particular, tricuspid valve mechanical behavior has not been accurately studied. In addition, there is no precise analytical and/or computerized model to predict the mechanical responses of the valve under normal and pathological conditions. In the current study, we have used biaxial tensile testing, small angle light scattering, ex-vivo passive heart beating simulation, and sonomicrometry techniques to quantify the mechanical characteristics, microstructure, dynamic deformations, and geometric parameters of the tricuspid valve. We aimed to develop a more accurate computerized model of the tricuspid valve for simulation purposes. Our studies are important both for understanding the normal valvular function as well as for development/improvement of surgical procedures and medical devices.
Rouzbeh Amini, Dr. (Advisor)
Brian Davis, Dr. (Committee Member)
Ge Zhang, Dr. (Committee Member)
Francis Loth, Dr. (Committee Member)
Rolando Ramirez, Dr. (Committee Member)
224 p.
Anatomy and Physiology; Biomechanics; Biomedical Engineering; Biomedical Research; Engineering; Surgery; Technology
Tricuspid Valve; Biaxial Tensile Testing, Ex-vivo; Sonomicrometry; Surface Strains; Annulus Deformation; Tissue Mechanical Response; Constitutive Model; Material Model; Phenomenological; Simulation; Abaqus; Fung-type; Material Parameter; Valve Deformation

Recommended Citations

Citations

  • Amini Khoiy, K. (2018). Biomechanical Characterization and Simulation of the Tricuspid Valve [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1542651986497595

    APA Style (7th edition)

  • Amini Khoiy, Keyvan. Biomechanical Characterization and Simulation of the Tricuspid Valve. 2018. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1542651986497595.

    MLA Style (8th edition)

  • Amini Khoiy, Keyvan. "Biomechanical Characterization and Simulation of the Tricuspid Valve." Doctoral dissertation, University of Akron, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1542651986497595

    Chicago Manual of Style (17th edition)

akron1542651986497595
312
© 2018, all rights reserved.
This open access ETD is published by University of Akron and OhioLINK.