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Development of Polyacrylamide-Based Biomaterials in Hydrogels and Brushes

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2019, Doctor of Philosophy, University of Akron, Chemical Engineering.
The introduction of polyacrylamide with substantial amide groups (-CONH-) enables the formation of large amount of hydrogen bonds in polymer systems. Hydrogen bonds play a significant role on the formation of the hydration layer on antifouling brush surfaces and work as reversible, dynamic and physical crosslinkers to endow hydrogels with high mechanical and recoverable properties. Herein, two kinds of acrylamide monomers (N-acryloyl glycinamide(NAGA), N-hydroxyethyl acrylamide (HEAA)) are employed to prepare the multifunctional biomaterials via different preparation methods based on different design strategies. NAGA monomer contains two amide groups (-CONH-) and one carbon space length between them. HEAA monomer contains one amide group (-CONH-), one hydroxyl group (-OH), and two carbon space lengths between them. We first synthesized NAGA monomer and prepared poly(NAGA) brushes via surface-initiated atom transfer radical polymerization (SI-ATRP) (Chapter II). The poly(NAGA) brushes with optimal thickness demonstrated their excellent antifouling ability by resisting protein adsorption from undiluted serum and plasma, bacterial attachment and cell attachments for up to 3 days. Molecular simulation results indicated a positive relationship between high surface hydrophilicity and high surface resistance ability. We fabricated polyHEAA-methyl acrylate (MA)@Tween80 hydrogels via emulsion copolymerization (Chapter III). The resultant hydrogels demonstrated their high comprehensive mechanical properties (high fracture stress of 700 kPa, high fracture strain of 1687 mm/mm, high elastic modulus of 195 kPa, and high tearing energy of 1598 J/m2) at optimal conditions and fast stiffness/toughness recovery of 60%/33% without any stimuli. The highly tough and recoverable hydrogels could be used in wide and long-time applications such as artificial tendons or cartilages, hydrogel electronics and wound dressing.
Jie Zheng, PhD (Committee Chair)
Zhenmeng Peng, PhD (Committee Member)
Lingyun Liu, PhD (Committee Member)
Ge Zhang, PhD (Committee Member)
Xiong Gong, PhD (Committee Member)
89 p.

Recommended Citations

Citations

  • Yang, F. (2019). Development of Polyacrylamide-Based Biomaterials in Hydrogels and Brushes [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555603442979042

    APA Style (7th edition)

  • Yang, Fengyu. Development of Polyacrylamide-Based Biomaterials in Hydrogels and Brushes. 2019. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1555603442979042.

    MLA Style (8th edition)

  • Yang, Fengyu. "Development of Polyacrylamide-Based Biomaterials in Hydrogels and Brushes." Doctoral dissertation, University of Akron, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555603442979042

    Chicago Manual of Style (17th edition)