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EFFECT OF SODIUM DODECYL SULFATE ON THE STRUCTURE AND RHEOLOGICAL PROPERTIES OF PLURONIC F108 - POLY(ACRYLIC ACID) COACERVATES

Ziyuan, Gong
http://rave.ohiolink.edu/etdc/view?acc_num=akron1555681739197109

Abstract Details

2019, Master of Science in Polymer Engineering, University of Akron, Polymer Engineering.
Coacervate is the aggregate of polymer-rich colloidal droplet formed via liquid-liquid phase separation, resulting from electrostatic interaction, or from hydrogen-bond formation. The micelle formation of Pluronic F108 and the large amount of ether oxygens in Pluronic F108 provides opportunity to fabricate PAA/Pluronic F108 coacervate with F108 micelle core. This coacervate containing micelle structure can find applications in drug delivery platform, DNA transportation vehicle as well as personal products. The structure of the coacervate – micelle is related to the viscoelastic property, which is the key to their utilities. One challenge of the PAA/F108 coacervate is difficultly in manipulating the micelle structure as well as tuning the coacervate to obtain the desire rheological property in a limited range of temperature and pH value. In this work, a method to modulate the Pluronic F108 micelle structure and tune the rheological property of PAA/F108 coacervate was developed. Mixing PAA, F108 solution can lead to formation of viscoelastic liquid coacervate with Pluronic F108 micelle core. The alkyl tail of sodium dodecyl sulfate (SDS) can bind the hydrophobic PPO block of Pluronic F108 copolymer in the aqueous solution due to hydrophobic interaction and increase the hydrophilicity of whole polymer chain, which leads to suppress the formation of Pluronic F108 micelle. This interaction leads to larger water content in the coacervate (from 52% to 65%) with additional SDS in the initial solution. Small angle X-ray scattering (SAXS) experiment demonstrates that Pluronic F108 micelle structure in the coacervate cannot persist when [SDS]Sol > 4mM. This lack of micelle structure instead of the increasing water content in the coacervate leads to the decreasing moduli according to rheological characterization (SAOS). Additionally, the loss factor (tan δ) of PAA/F108 coacervate initially increases linearly with additional SDS, but a sharp increase occurs near the critical micelle concentration of SDS and remains constant with a wide range of [SDS]Sol. However, this change does not relate to the micellization of SDS in the coacervate according to the SAXS pattern. This shows that These results prove that the rheological properties of coacervate can be tuned by changing the Pluronic F108 micelle structure. This work could be significant for the biomaterial based coacervate - micelle system if other surfactants such as lipid can similarly impact the structure and rheological properties. However, additional work is needed to determine the generality of these findings in terms of the surfactant and the coacervate with micelle core.
Bryan Vogt (Advisor)
Nicole Zacharia (Advisor)
Ruel McKenzie (Committee Chair)
Kevin Cavicchi (Committee Member)
74 p.
Polymers

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Citations

  • Ziyuan, G. (2019). EFFECT OF SODIUM DODECYL SULFATE ON THE STRUCTURE AND RHEOLOGICAL PROPERTIES OF PLURONIC F108 - POLY(ACRYLIC ACID) COACERVATES [Master's thesis, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555681739197109

    APA Style (7th edition)

  • Ziyuan, Gong. EFFECT OF SODIUM DODECYL SULFATE ON THE STRUCTURE AND RHEOLOGICAL PROPERTIES OF PLURONIC F108 - POLY(ACRYLIC ACID) COACERVATES. 2019. University of Akron, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1555681739197109.

    MLA Style (8th edition)

  • Ziyuan, Gong. "EFFECT OF SODIUM DODECYL SULFATE ON THE STRUCTURE AND RHEOLOGICAL PROPERTIES OF PLURONIC F108 - POLY(ACRYLIC ACID) COACERVATES." Master's thesis, University of Akron, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555681739197109

    Chicago Manual of Style (17th edition)

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