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SYNTHESIS, CHARACTERIZATION, AND MATERIAL PROPERTIES OF IONIC THIOL-YNE ELASTOMERS

Nettleton, Jason William

Abstract Details

2020, Doctor of Philosophy, University of Akron, Polymer Science.
Mechanical and Antimicrobial Properties of Degradable Quaternary Ammonium Compound Thiol-yne Elastomers. Antimicrobial polymers are an important biomedical material for preventing bacterial infections of implanted devices. Antimicrobial activity is frequently granted through surface-functionalization with contact-killing moieties or delivery or biocidal agents blended with the polymer matrix. These methods have drawbacks which bulk-functionalization can overcome. Quaternary ammonium compounds with various alkyl tail lengths were functionalized onto a dithiol monomer for polymerization with a novel alkyl propiolate monomer into degradable thiol-yne polymers with tunable mechanical properties. Tensile properties, cytocompatibility, and antimicrobial activity of these polymers were evaluated to assess their use as elastic biomaterials. Degradable, Mechanically Tunable Tissue Adhesives from Phosphonate-Functionalized Thiol-yne Elastomers. Tissue adhesives are biomaterials used to close skin lacerations, bind bone fragments, and form strong bonds between artificial joint replacements and bone. Commercial tissue adhesives are limited to toxic cyanoacrylates for soft tissue repair and non-adhesive, non-degradable poly(methyl methacrylate) bone cement. A novel thiol-yne elastomer was synthesized with polypropylene glycol segments added to improve solubility in clinically relevant solvents. A phosphonate-functionalized dithiol monomer was also synthesized to see if ionic interactions with the mineral composites in bone could be utilized to improve adhesion. Synthesis and Characterization of Elastic Sulfonate-Functionalized Thiol-yne Polymers for Conductive Composites. Flexible and elastic electronics are a heavily researched field with applications in medicine and technology. Soft, degradable, and elastic materials are needed which can provide both ionic and electrical conductivity. Sulfonate-functionalized thiol-yne elastomers were synthesized and tested for their hydrolytic degradability and tensile properties. The polymers were evaluated for their potential as composite materials blended with electrically conductive fillers.
Matthew Becker (Advisor)
Andrey Dobrynin (Committee Member)
Kevin Cavicchi (Committee Member)
Xiong Gong (Committee Member)
Yu Zhu (Committee Member)
129 p.

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Citations

  • Nettleton, J. W. (2020). SYNTHESIS, CHARACTERIZATION, AND MATERIAL PROPERTIES OF IONIC THIOL-YNE ELASTOMERS [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1596473776260031

    APA Style (7th edition)

  • Nettleton, Jason. SYNTHESIS, CHARACTERIZATION, AND MATERIAL PROPERTIES OF IONIC THIOL-YNE ELASTOMERS. 2020. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1596473776260031.

    MLA Style (8th edition)

  • Nettleton, Jason. "SYNTHESIS, CHARACTERIZATION, AND MATERIAL PROPERTIES OF IONIC THIOL-YNE ELASTOMERS." Doctoral dissertation, University of Akron, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1596473776260031

    Chicago Manual of Style (17th edition)