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SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS

Freedman, Abegel
http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688

Abstract Details

2020, Doctor of Philosophy, University of Akron, Polymer Science.
Poly(ethylene glycol) (PEG) is a ubiquitous polymer in the biomaterials and drug delivery fields. PEG is thought to be nonimmunogenic and prolongs the half-life of circulating drug delivery vehicles. Most applications utilize methyl ether PEG (mPEG) with a linear architecture. The first part of this dissertation involves the synthesis of linear and cyclic (m)PEG based benzyl (meth)acrylate monomers for future lower critical solution temperature (LCST) studies. This will give the biomaterials field valuable insights into how the architecture of PEG affects the thermoresponsive properties of PEG containing polymers. The drug delivery field also primarily uses linear mPEG to evade protein adsorption. However, recent reports found that PEGylated drug delivery vehicles elicit an immune response upon multiple doses. Thus, the drug delivery field can benefit from a technique that directly detects protein adsorption onto PEGylated drug delivery vehicles at low concentrations. The second part of this dissertation focuses on utilizing fluorescence cross-correlation spectroscopy (FCCS) to detect protein adsorption onto micelles with varying PEG architectures. mPEG-polycaprolactone (PCL) was used to form micelles with a linear architecture and PCL-PEG-PCL was used to form micelles with a “cyclic” architecture. FCCS demonstrated that more bovine serum albumin (BSA) adsorbed onto PCL-PEG-PCL micelles than the mPEG-PCL micelles. It also revealed different adsorption trends, as mPEG-PCL had delayed interactions with BSA, after 12 hours, while PCL-PEG-PCL had immediate interactions with a plateau after 12 hours.
Coleen Pugh, Dr. (Advisor)
Tianbo Liu, Dr. (Committee Chair)
Abraham Joy, Dr. (Committee Member)
Chrys Wedemiotis, Dr. (Committee Member)
Adam Smith, Dr. (Committee Member)
Polymer Chemistry

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Citations

  • Freedman, A. (2020). SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS [Doctoral dissertation, University of Akron]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688

    APA Style (7th edition)

  • Freedman, Abegel. SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS. 2020. University of Akron, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688.

    MLA Style (8th edition)

  • Freedman, Abegel. "SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS." Doctoral dissertation, University of Akron, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Akron and OhioLINK.