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A PROFILE OF NEUROGENIC ACTIVITY IN THE AGING HIPPOCAMPAL FORMATION: A CLOSER LOOK AT THE ROLE OF EXERCISE AND ENVIRONMENTAL ENRICHMENT IN THE SAMP-8

Fortress, Ashley M.
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1178197418

Abstract Details

2007, Master of Arts (MA), Bowling Green State University, Psychology/Experimental.
Neurogenesis is a process of neuronal proliferation that is most prominent during development but has recently been found in adulthood. This phenomenon occurs naturally in the hippocampal formation of many mammalian species, including humans. Various factors influence neurogenesis, such as age, voluntary exercise and environmental enrichment. The present study was performed to determine the profile of the age-related decline of neurogenesis in the senescence accelerated mouse (SAMP8). Additionally, the ability of exercise and environmental enrichment to independently reverse the age-related decline of neurogenesis was investigated. Four age groups of male SAMP8 mice were examined: 2-, 5-, 7- and 12-months. Assessing both survival and proliferation using immunocytochemistry for BrdU and Ki67, it was found that: (1) exercise showed a trend for reversing the age-related decline in neurogenesis (2) environmental enrichment significantly decreased neurogenesis in the 2-month old age group and had no effect for all other age groups when compared to isolated animals (3) neither exercise nor enrichment was beneficial in promoting survival.
Kevin Pang (Advisor)
73 p.
Neurogenesis; Hippocampus; Aging; BrdU; Ki67; Exercise; Environmental Enrichment

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Citations

  • Fortress, A. M. (2007). A PROFILE OF NEUROGENIC ACTIVITY IN THE AGING HIPPOCAMPAL FORMATION: A CLOSER LOOK AT THE ROLE OF EXERCISE AND ENVIRONMENTAL ENRICHMENT IN THE SAMP-8 [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1178197418

    APA Style (7th edition)

  • Fortress, Ashley. A PROFILE OF NEUROGENIC ACTIVITY IN THE AGING HIPPOCAMPAL FORMATION: A CLOSER LOOK AT THE ROLE OF EXERCISE AND ENVIRONMENTAL ENRICHMENT IN THE SAMP-8. 2007. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1178197418.

    MLA Style (8th edition)

  • Fortress, Ashley. "A PROFILE OF NEUROGENIC ACTIVITY IN THE AGING HIPPOCAMPAL FORMATION: A CLOSER LOOK AT THE ROLE OF EXERCISE AND ENVIRONMENTAL ENRICHMENT IN THE SAMP-8." Master's thesis, Bowling Green State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1178197418

    Chicago Manual of Style (17th edition)

bgsu1178197418
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© 2007, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.