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Voluntary Wheel Running Alters Brain-Derived Neurotrophic Factor Levels in the Hippocampus of Senescence Accelerated Mice

Janke, Kellie
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1237829856

Abstract Details

2009, Master of Arts (MA), Bowling Green State University, Psychology/Experimental.
Brain-derived neurotrophic factor (BDNF) promotes neuronal development and survival. BDNF and its high affinity receptor, trkB, are extensively expressed in the mammalian hippocampus, a structure susceptible to damage in neurodegenerative disorders such as Alzheimer’s disease. Current research in this field has shown voluntary wheel running to be an effective tool in increasing BDNF protein in the hippocampus, hence promoting cell survival within this structure. The SAMP8 mouse line exhibits accelerated senescence of learning and memory and has been a good model of aging and Alzheimer’s disease. Therefore, the present study investigated the effects of 21 days of voluntary wheel running on total BDNF and free mature BDNF in the hippocampus of young (1-3 months), middle-aged (5-8 months) and old (10 months +) SAMP8 mice. BDNF levels in the SAMP8 hippocampus were measured by sandwich ELISA. In sedentary mice, females showed an increase in total BDNF and mature BDNF protein across the lifespan while male SAMP8 showed a reduction of both in middle-age. Exercise successfully increased total protein content in the hippocampus of young, middle-age, and old female and male SAMP8. Voluntary wheel running also increased mature BDNF at each age group for each sex, similar to total BDNF, with the exception of young males. The increase of BDNF in response to voluntary wheel running declined with age in the females. No significant difference was found between the running distance of males and females in each group. However, young mice ran significantly farther than the middle-aged or old animals and running distance was correlated with total BDNF increase. Overall, aging was shown to be the primary factor in decreasing the effectiveness of exercise to increase BDNF.
Kevin Pang, PhD (Committee Chair)
Pat Sharp, PhD (Committee Member)
Tami Steveson, PhD (Committee Member)
45 p.
Psychology
BDNF; Exercise; Hippocampus

Recommended Citations

Citations

  • Janke, K. (2009). Voluntary Wheel Running Alters Brain-Derived Neurotrophic Factor Levels in the Hippocampus of Senescence Accelerated Mice [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1237829856

    APA Style (7th edition)

  • Janke, Kellie. Voluntary Wheel Running Alters Brain-Derived Neurotrophic Factor Levels in the Hippocampus of Senescence Accelerated Mice. 2009. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1237829856.

    MLA Style (8th edition)

  • Janke, Kellie. "Voluntary Wheel Running Alters Brain-Derived Neurotrophic Factor Levels in the Hippocampus of Senescence Accelerated Mice." Master's thesis, Bowling Green State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1237829856

    Chicago Manual of Style (17th edition)

bgsu1237829856
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© 2009, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.