Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


bgsu1245695407.pdf (938.94 KB)

ETD Abstract Container

Abstract Header

Comparison Between PCB Exposure and Hypothyroidism: Behavioral Development in Sprague-Dawley Rats

Toth, Cynthia L.
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245695407

Abstract Details

2009, Master of Science (MS), Bowling Green State University, Biological Sciences.
Manufactured to take advantage of their chemical and thermal stability, polychlorinated biphenyls (PCB) are persistent environmental endocrine disruptors used from 1929 to 1977 in the synthesis of plastics, and for coolants in transformers and other dielectrics. Improper handling and disposal has led to environmental contamination and has been linked to physiological, behavioral, and neural disruptions in children and various model species. Many deficits observed in perinatal PCB exposed animals, such as poor memory and subnormal attention proficiency, hypo- and hyperactivity, and poor motor reflexes, are seemingly analogous to other chronic conditions such as congenital hypothyroidism. Using two varying doses of thiouracil to induce hypothyroidism, the present study aimed to compare PCB exposure to hypothyroidism by observing three different behavioral tests. Ultrasonic vocalizations emitted when isolated from the dam, conditioned odor preference (COP) paradigm, and observing an innately sequenced behavior like the grooming chain provide three ways to observe different aspects of social and motor function during development. There was no observed statistical significance in the number of isolation distress calls emitted regardless of treatment. The COP yielded differences between the PCB- and thiouracil-fed animals while the PCB was nearly identical to the control group. Grooming yielded a delay in the formation of complete perfect grooming chains at postnatal day (PND) 15 to 16 yet the PCB and higher thiouracil dose were able to draw nearer to the controls in grooming success by PND 30-31 and 60-61. The current study shows that PCB may be similar to either dose of thiouracil depending on the age of the rat.
Lee A. Meserve, PhD (Advisor)
Howard Casey Cromwell, PhD (Committee Member)
Carmen Fioravanti, PhD (Committee Member)
51 p.
Biology
polychlorinated biphenyls; hypothyroidism; thiouracil, thyroid hormones; grooming

Recommended Citations

Citations

  • Toth, C. L. (2009). Comparison Between PCB Exposure and Hypothyroidism: Behavioral Development in Sprague-Dawley Rats [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245695407

    APA Style (7th edition)

  • Toth, Cynthia. Comparison Between PCB Exposure and Hypothyroidism: Behavioral Development in Sprague-Dawley Rats. 2009. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245695407.

    MLA Style (8th edition)

  • Toth, Cynthia. "Comparison Between PCB Exposure and Hypothyroidism: Behavioral Development in Sprague-Dawley Rats." Master's thesis, Bowling Green State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245695407

    Chicago Manual of Style (17th edition)

bgsu1245695407
860
© 2009, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.