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OXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF PURINE QUINONES AND DEVELOPMENT OF NOVEL PHOTOOXIDIZING AGENTS

Komarov, Dmitry Yurievich
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1285956212

Abstract Details

2010, Doctor of Philosophy (Ph.D.), Bowling Green State University, Photochemical Sciences.
Chemical behavior of the oxopurines 8-oxoadenosine and 8-oxoinosine has been investigated. Purine quinones, pivotal intermediates in oxidation of oxopurines were successfully trapped and the resulting products were characterized. Formation of purine quinones was demonstrated with both chemical and photochemical oxidizing agents. Adducts formed as a result of reaction of purine quinones with nucleophiles were isolated and characterized. Pyrene dihydrodioxins have been synthesized and shown to be effective agents for release of pyrene-4,5-dione. Pyrene-4,5-dione is an effective DNA photo-oxidation agent. Pyrene dihydrodioxin incorporating a pyridinium salt as a possible internal electron trap has been shown to release pyrenequinone rapidly. Dihydrodioxins containing two pyridine and pyridinium salt moieties have been synthesized and characterized by variety of methods including 1H and 13C NMR spectroscopy. Dihydrodioxin containing two pyridine moieties was separated into D and L enantiomers via liquid chromatography on a chiral sorbent. Affinities of D and L enantiomers of these dipyridinium pyrene dihydrodioxins for nucleic acids were compared.
R. Marshall Wilson, PhD (Advisor)
Neocles B. Leontis, PhD (Committee Member)
Thomas H. Kinstle, PhD (Committee Member)
Warren W. McGovern, PhD (Committee Member)
105 p.
Chemistry
oxopurines; 8-oxoadenosine; 8-oxoinosine; cross-linking; dihydrodioxins; photooxidizing agents; DNA intercalator

Recommended Citations

Citations

  • Komarov, D. Y. (2010). OXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF PURINE QUINONES AND DEVELOPMENT OF NOVEL PHOTOOXIDIZING AGENTS [Doctoral dissertation, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1285956212

    APA Style (7th edition)

  • Komarov, Dmitry. OXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF PURINE QUINONES AND DEVELOPMENT OF NOVEL PHOTOOXIDIZING AGENTS. 2010. Bowling Green State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1285956212.

    MLA Style (8th edition)

  • Komarov, Dmitry. "OXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF PURINE QUINONES AND DEVELOPMENT OF NOVEL PHOTOOXIDIZING AGENTS." Doctoral dissertation, Bowling Green State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1285956212

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Bowling Green State University and OhioLINK.