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Molecular basis of group A colicin/TolA recognition in Enterobacter species

Zook, Dana M.

Abstract Details

2011, Master of Science (MS), Bowling Green State University, Biological Sciences.
The Tol protein system is a set of proteins found between the cytoplasmic and outer membranes of Gram negative bacteria. The central component of this system is the protein TolA. The exact physiological function of both the protein system and TolA specifically remains to be determined; however data suggest a role in maintaining the integrity of the outer membrane. In addition to this hypothesized physiologic role, the Tol system has been shown to be parasitized by both filamentous bacteriophage and the toxic colicin proteins. The TolA protein is believed to facilitate the translocation of the phage and colicins across the periplasmic space. The present study characterizes phylogenetically conserved features of the TolA protein that contribute to sensitivity to group A colicins. This study provides insight into the molecular features of the protein-protein interactions involved in the translocation of group A colicins.
Ray Larsen, PhD (Advisor)
Scott Rogers, PhD (Committee Member)
Vipaporn Phuntumart, PhD (Committee Member)
65 p.

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Citations

  • Zook, D. M. (2011). Molecular basis of group A colicin/TolA recognition in Enterobacter species [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1300564452

    APA Style (7th edition)

  • Zook, Dana. Molecular basis of group A colicin/TolA recognition in Enterobacter species. 2011. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1300564452.

    MLA Style (8th edition)

  • Zook, Dana. "Molecular basis of group A colicin/TolA recognition in Enterobacter species." Master's thesis, Bowling Green State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1300564452

    Chicago Manual of Style (17th edition)