Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


Nina Esipenko 04-09-2014.pdf (12.01 MB)

ETD Abstract Container

Abstract Header

Design, Synthesis, and Application of Sensors for Biologically Relevant Molecules

Esipenko, Nina A
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1395589938

Abstract Details

2014, Doctor of Philosophy (Ph.D.), Bowling Green State University, Photochemical Sciences.
Nowadays, our society is facing numerous ecological, chemical, and medical challenges that could be met with new scientific discoveries. Among these scientific studies are the qualitative and quantitative analytical determinations of chemical and biological species associated with such challenges. Design and synthesis of chemical sensors capable of operating in a complex media are of crucial importance due to their potential application in the environmental and biological processes. Fluorescence based sensors are gaining wide popularity for chemical trace detection due to their high sensitivity and low cost. Chemical sensors that operate based on specific analyte-induced changes in fluorescence appear particularly attractive because they offer the potential for detecting low analyte concentrations. The present work describes the application of different types of fluorescence-based sensors designed to distinguish various structurally similar analytes, analyte mixtures as well as specific analytes in a complex media such as blood serum and urine. Here, we describe efficient methods for sensing several analytes of interest such as ovarian cancer biomarker, cancer associated nitrosamines, drug-related amines with potential for abuse and pyrophosphate in real-time PCR monitoring. Our work is a contribution to the development of practical laboratory procedures tackling challenges of our society.
Pavel Anzenbacher, PhD (Advisor)
George Bullerjahn, PhD (Committee Member)
Andrew Torelli, PhD (Committee Member)
Andrew Layden , PhD (Committee Member)
210 p.
Analytical Chemistry
Chemical sensor, fluorescence, sensor array, polymerase chain reaction, folate receptor alpha, nitrosamines, cucurbituril-type receptors, pyrophosphate

Recommended Citations

Citations

  • Esipenko, N. A. (2014). Design, Synthesis, and Application of Sensors for Biologically Relevant Molecules [Doctoral dissertation, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1395589938

    APA Style (7th edition)

  • Esipenko, Nina. Design, Synthesis, and Application of Sensors for Biologically Relevant Molecules. 2014. Bowling Green State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1395589938.

    MLA Style (8th edition)

  • Esipenko, Nina. "Design, Synthesis, and Application of Sensors for Biologically Relevant Molecules." Doctoral dissertation, Bowling Green State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1395589938

    Chicago Manual of Style (17th edition)

bgsu1395589938
933
© 2014, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.