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The Role of Calcium Flux in the Regulation of Filopodia Dynamics

Ademuyiwa, Omolade Mary
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1562940435730486

Abstract Details

2019, Master of Science (MS), Bowling Green State University, Biological Sciences.
Filopodia are finger-like projections on cells that allow the cells to sense and explore their external microenvironment. They are required for cell migration, neurogenesis and several other physiological processes. Filopodia dynamics have been widely studied in nerve cells. Here, I investigated the role of increased cytoplasmic calcium levels in the regulation of filopodia through activation of store-operated calcium entry in epithelial cells. The depletion of the endoplasmic reticulum store caused a transient increase in filopodia. The increase in fraction of cells with filopodia and percentage coverage of filopodia was seen at 10 min followed by a decrease at 30 min of treatment with cyclopiazonic acid (CPA). Filopodia dynamics are more sensitive to and regulated by Transient receptor potential cation (TRPC) channels. The downstream effectors of calcium such as calpain and calmodulin are negative regulators of filopodia. The possible mechanisms by which calcium regulates filopodia through these downstream effectors were reported here. The effect of calcium-like protein 2 (CALP2) in filopodia dynamics was first described in this study.
Carol Heckman, Ph.D (Advisor)
Michael Geusz, Ph.D (Committee Member)
David Giovannucci, Ph.D (Committee Member)
71 p.
Biology
Filopodia; calcium; signaling

Recommended Citations

Citations

  • Ademuyiwa, O. M. (2019). The Role of Calcium Flux in the Regulation of Filopodia Dynamics [Master's thesis, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1562940435730486

    APA Style (7th edition)

  • Ademuyiwa, Omolade. The Role of Calcium Flux in the Regulation of Filopodia Dynamics. 2019. Bowling Green State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1562940435730486.

    MLA Style (8th edition)

  • Ademuyiwa, Omolade. "The Role of Calcium Flux in the Regulation of Filopodia Dynamics." Master's thesis, Bowling Green State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1562940435730486

    Chicago Manual of Style (17th edition)

bgsu1562940435730486
583
© 2019, all rights reserved.
This open access ETD is published by Bowling Green State University and OhioLINK.