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Central Metabolic Substrates of Food Intake Regulation

Meeker, Rick
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu156646304850526

Abstract Details

1976, Doctor of Philosophy (Ph.D.), Bowling Green State University, Psychology.
The hypothalamus of 144 ad lib fed, male, Long-Evans hooded rats was extensively mapped for sites in which metabolic substrates (D-glucose, beta-hydroxybutyrate), metabolic inhibitors (2,4 dinitrophenol, malonate), amino acids (gamma-aminobutyric acid, glutamic acid, glutamine, gamma-hydroxybutyric acid), and pharmacological manipulations of gamma-aminobutyric acid metabolism (aminooxyacetic acid, bicuculline) altered feeding behavior. Brain injections were made through chronically implanted cannulae into hypothalamic sites known to participate in the organization of feeding behavior. Short-term (1, 2, and 4 hours) and long-term (24 hours) feeding patterns were analyzed for each substance injected and compared to feeding patterns following a control substance injected into the same region. A region was identified along the base of the brain lateral to the ventromedial nucleus (basolateral VMH) from which a consistent pattern of feeding responses was found which was indicative of a metabolically sensitive regulatory system. After a minimum latency of four hours, D-glucose injections into the basolateral VMH decreased food intakes and 2,4 dinitrophenol injections increased food intakes. Gamma-aminobutyric acid (GABA) and amino-oxyacetic acid (AOAA) injections produced immediate decreases in food intake which continued for 24 hours. Food intakes were unaffected following 155 mM saline, L-glucose, beta-hydroxybutyrate, malonate, glutamate, glutamine, and gamma-hydroxybutyrate injections into the basolateral VMH. Support was also obtained for GABA-minergic synapses within the ventromedial nucleus of the hypothalamus and the paraventricular-anterior hypothalamic region which promote satiety. Combined, the data support the existence of cells within the basolateral VMH which are sensitive to metabolic flux and which may exert inhibitory control over food intake via local release of GABA as well as afferent GABA-minergic projections to the paraventricular-anterior hypothalamic region and the ventromedial nucleus. Fluctuations in the release of GABA which parallel glucose metabolism allow the animal to titrate its feeding response and consequently regulate caloric intake over extended periods of time.
Jaak Panksepp (Advisor)
Psychology

Recommended Citations

Citations

  • Meeker, R. (1976). Central Metabolic Substrates of Food Intake Regulation [Doctoral dissertation, Bowling Green State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu156646304850526

    APA Style (7th edition)

  • Meeker, Rick. Central Metabolic Substrates of Food Intake Regulation. 1976. Bowling Green State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=bgsu156646304850526.

    MLA Style (8th edition)

  • Meeker, Rick. "Central Metabolic Substrates of Food Intake Regulation." Doctoral dissertation, Bowling Green State University, 1976. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu156646304850526

    Chicago Manual of Style (17th edition)

bgsu156646304850526
139
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