Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1164830757.pdf (634.13 KB)

ETD Abstract Container

Abstract Header

Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism

Miller, Katherine
http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757

Abstract Details

2007, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
With significant evidence supporting the role of lipid transport and/or lipid metabolism in late onset Alzheimer’s Disease (LOAD) susceptibility, we hypothesized that polymorphisms in genes coding for proteins involved in lipid pathways would make good candidates in an investigation of genetic risk and LOAD. We selected six genes associated both with LOAD and either directly or indirectly with lipid pathways to test in three case-control populations: Brain-derived Neurotrophic Factor (BDNF), Transthyretin (TTR), Tumor Necrosis Factor alpha (TNFa), Low-density Lipoprotein Receptor-related Protein (LRP1), Apolipoprotein L-3 (APOL3), and Sterol O-acyltransferase 1 (SOAT1). As an additional, exploratory analysis, we tested the hypothesis that dietary intake of lipids may modify the effect of these genes. Our results demonstrate a potentially significant role of LRP1 in protection against LOAD in the younger LOAD case-control population. In the elderly LOAD case-control population, we observed an association of borderline significance for TNFa, APOL3, and BDNF. Additional results of interest include observed but statistically non-significant effect modification of TTR by dietary fish intake.
Katrina Goddard (Advisor)
SNP; DOM1; DOM2; LRP1; DISEASE; BDNF; allele

Recommended Citations

Citations

  • Miller, K. (2007). Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757

    APA Style (7th edition)

  • Miller, Katherine. Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism. 2007. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757.

    MLA Style (8th edition)

  • Miller, Katherine. "Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism." Doctoral dissertation, Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757

    Chicago Manual of Style (17th edition)

case1164830757
975
© 2006, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.