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ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

Wang, Hui
http://rave.ohiolink.edu/etdc/view?acc_num=case1207178563

Abstract Details

2008, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
In this thesis, I first demonstrate three novel broad band light sources at above 1 µm for ultra-high resolution optical coherence tomography (OCT) based on multiple SLED combination and supercontinuum generation. The light sources are compact, reliable, smooth and ready for practical applications. The images achieved with those light sources showed superior quality in comparison to the images achieved under normal resolution OCT with axial resolution around 12 to 15 µm. In the second part of the thesis, the feasibility of using gold nanorod (NR) as a probe for contrast sensitive OCT is described. Two methods, photothermal effect (PT) and spectroscopic analysis, have been investigated. The method based on PT cannot provide sufficient contrast for imaging due to the thermal lensing effect. Although external modulation is preferred for contrast sensitive OCT, more sophisticated probes are required in future studies. In spectroscopic analysis, contrast due to absorption and scattering of NR has been observed. However, absorption is dominant for the small size of NR used here. Larger NR will be advantageous for use as a scattering probe and for avoiding the ambiguity of contrast sensitive OCT. In the last part of the thesis, three biological applications are demonstrated. The results show that intact mouse embryo and fiber orientation of intact mouse heart can be readily imaged with ultrahigh resolution OCT. These findings pave the way for future imaging, with a high speed system, of those subjects in living states. As an additionally investigated application, the sliver glucose sensor was imaged in the mouse skin. For reliably tracking sensors with OCT, the implant depth should be around the interface of the epidermis and dermis. For tracking of the inflammation process over the long term, multiple optical imaging modalities may be required.
Andrew Rollins (Committee Chair)
Kenneth Singer (Committee Member)
Clemens Burda (Committee Member)
Lee Zhenghong (Committee Member)
Miklos Gratzl (Committee Member)
Biomedical Research; Engineering; Optics
optical coherence tomography; supercontinuum generation; gols nano rod; contrast sensitive;

Recommended Citations

Citations

  • Wang, H. (2008). ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1207178563

    APA Style (7th edition)

  • Wang, Hui. ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY. 2008. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1207178563.

    MLA Style (8th edition)

  • Wang, Hui. "ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY." Doctoral dissertation, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207178563

    Chicago Manual of Style (17th edition)

case1207178563
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© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.