Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


case1212612650.pdf (6.05 MB)

ETD Abstract Container

Abstract Header

Properties of Poly(ethylene glycol) Diacrylate Blends and Acoustically Focused Multilayered Biocomposites Developed for Tissue Engineering Applications

Mazzoccoli, Jason Paul
http://rave.ohiolink.edu/etdc/view?acc_num=case1212612650

Abstract Details

2008, Master of Sciences, Case Western Reserve University, Chemical Engineering.
This research highlights the use poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA blends with molecular weights of 400 and 3400 were UV crosslinked to photoencapsulate mammalian cells at total polymer concentrations that were varied systematically from 20 to 40 wt %. Initial cell viability was determined via a fluorescent LIVE/DEAD assay and was reduced from 80 to 35% when increasing total polymer concentrations from 20 to 40 wt %. Hydrogels were produced with compressive moduli exceeding 1 MPa; however cell viability decreases as the modulus increases. These preliminary results can be exploited for cartilage tissue development to produce a mechanically strong scaffold. Additional experiments used acoustic fields to create multi-layered biocomposites from similar materials. Acoustic focusing should prove useful as a tool to enhance tissue development by optimizing cell-cell contact within the polymer matrix, at reduced initial cell loadings, by concentrating cells into bands.
Donald Feke, PhD (Committee Chair)
Peter Pintauro, PhD (Committee Member)
Harihara Baskaran, PhD (Committee Member)
101 p.
Biomedical Research
hydrogel; cell encapsulation; tissue engineering; acoustic focusing; ultrasonic standing wave; poly(ethylene glycol) diacrylate

Recommended Citations

Citations

  • Mazzoccoli, J. P. (2008). Properties of Poly(ethylene glycol) Diacrylate Blends and Acoustically Focused Multilayered Biocomposites Developed for Tissue Engineering Applications [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1212612650

    APA Style (7th edition)

  • Mazzoccoli, Jason. Properties of Poly(ethylene glycol) Diacrylate Blends and Acoustically Focused Multilayered Biocomposites Developed for Tissue Engineering Applications. 2008. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1212612650.

    MLA Style (8th edition)

  • Mazzoccoli, Jason. "Properties of Poly(ethylene glycol) Diacrylate Blends and Acoustically Focused Multilayered Biocomposites Developed for Tissue Engineering Applications." Master's thesis, Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1212612650

    Chicago Manual of Style (17th edition)

case1212612650
6,990
© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.