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Specific ECM Engagement Differentially Modulates T Cell Cytoskeletal Reorganization By Rho GTPases

Xue, Feng
http://rave.ohiolink.edu/etdc/view?acc_num=case1221770198

Abstract Details

2009, Master of Sciences, Case Western Reserve University, Pathology.
When T cells adhere to the ECM, under certain circumstances they will polarize and exhibit the morphology of a migrating cell. We are investigating three specific questions: (a) What environmental signals modulate T cell cytoskeletal reorganization, especially vimentin, the intermediate filament? (b) Which Rho GTPase is involved in vimentin polarization on discrete ECM ligands, such as collagen type I and fibronectin? (c) What is the mechanism and function of vimentin reorganization upon engagement of distinct ECM ligands? Our preliminary findings demonstrate that (a) certain but not all inside-out and outside-in signals lead to integrin activation that results in T cell cytoskeletal rearrangement, particularly vimentin polarization, on ECM ligands. (b) Rho GTPases differentially modulate vimentin polarization when T cells adhere to distinct ECM ligands. This work sets a base for further investigation of the potential role vimentin plays in lymphocyte migration and signaling.
Nicholas Ziats, PhD (Committee Chair)
Alan Levine, PhD (Advisor)
Steven Eppell, PhD (Committee Member)
Clive Hamlin, PhD (Committee Member)
Integrins; ECM; fibronectin; CELL; PBT; RHO GTPASES; GTPASES

Recommended Citations

Citations

  • Xue, F. (2009). Specific ECM Engagement Differentially Modulates T Cell Cytoskeletal Reorganization By Rho GTPases [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1221770198

    APA Style (7th edition)

  • Xue, Feng. Specific ECM Engagement Differentially Modulates T Cell Cytoskeletal Reorganization By Rho GTPases. 2009. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1221770198.

    MLA Style (8th edition)

  • Xue, Feng. "Specific ECM Engagement Differentially Modulates T Cell Cytoskeletal Reorganization By Rho GTPases." Master's thesis, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1221770198

    Chicago Manual of Style (17th edition)

case1221770198
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© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.