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A Human Genome Epidemiology Systematic Review of Endothelin Receptor-A

Doerr, Megan Jane
http://rave.ohiolink.edu/etdc/view?acc_num=case1228773764

Abstract Details

2009, Master of Sciences, Case Western Reserve University, Genetic Counseling.
The aims of this project were two-fold. The existing guidelines for HGE systematic review were examined and novel approaches to this process were proposed in Phase I of this project. Suggestions included organizing reviews by gene, analysis of data by linkage disequilibrium block, and the use of an audit tool to guide data mining. In Phase II, these advanced guidelines were implemented in a review of endothelin receptor-A (EDNRA). A five database literature draw-down yielded 267 unique abstracts for review. From these, 79 full-text studies were obtained; 24 studies met eligibility criteria. Analysis of the data was performed using the Venice Criteria (Ioannidis et al., 2008) and amalgamation by linkage disequilibrium block. While the Venice Criteria proved too stringent for the emergent EDNRA data set, analysis by linkage disequilibrium block yielded several trends including stratification of association by sex within block 1, synergistic associations with variants of endothelin-1 in block 3, and fairly strong associations with hypertension/blood pressure outcomes in block 4. This study provides advanced guidelines for HGE systematic review and evidence of their usefulness in practice.
Mitchell Drumm, PhD (Committee Chair)
Anna Mitchell, MD (Committee Member)
Anne Matthews, PhD (Committee Member)
170 p.
Epidemiology; Genetics
human genome epidemiology systematic review; systematic review; endothelin receptor-A; genetic association

Recommended Citations

Citations

  • Doerr, M. J. (2009). A Human Genome Epidemiology Systematic Review of Endothelin Receptor-A [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1228773764

    APA Style (7th edition)

  • Doerr, Megan. A Human Genome Epidemiology Systematic Review of Endothelin Receptor-A. 2009. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1228773764.

    MLA Style (8th edition)

  • Doerr, Megan. "A Human Genome Epidemiology Systematic Review of Endothelin Receptor-A." Master's thesis, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228773764

    Chicago Manual of Style (17th edition)

case1228773764
706
© 2008, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.