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Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes

Huang, Pinchia
http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814

Abstract Details

2009, Master of Sciences, Case Western Reserve University, Genetics.
Studies have shown that abnormal levels of individual prenatal screening markers are associated with an increased risk for obstetric complications unrelated to aneuploidy. The purpose of this descriptive cohort medical record review of pregnant patients was to examine the association between risk estimates or marker patterns and pregnancy complications. Prenatal screening and obstetric outcome data were analyzed for 120 screened-positive case subjects and 120 screened-normal controls. African American (AA) women with positive 2nd trimester trisomy 21 screens (n=95) had a statistically significant higher risk for intrauterine growth retardation (p=0.01) and low birth weight (p=0.019). AA women who experienced adverse pregnancy outcome, in particular low birth weight, had a higher inhibin-A level as compared to controls. However, aneuploidy risk estimates and marker patterns from 2nd trimester screens were not associated with increased risk for adverse pregnancy outcome. These findings provide empirical evidence for guiding pregnancy management plans for these patients.
Christine Curtis, PhD (Committee Chair)
Anne Matthews, PhD (Committee Member)
Patty Taneja, M.S. (Committee Member)
Anna Mitchell, M.D., PhD (Committee Member)
George VanBuren, M.D. (Committee Member)
86 p.
African Americans; Biomedical Research; Genetics; Health Care; Minority and Ethnic Groups; Obstetrics
prental screeening test; quad screens; first trimester screens; second trimester screens; first check; pregnancy complications; adverse pregnancy outcomes; obstetric complications; African American pregnancy; intrauterine growth retardation

Recommended Citations

Citations

  • Huang, P. (2009). Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814

    APA Style (7th edition)

  • Huang, Pinchia. Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes. 2009. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814.

    MLA Style (8th edition)

  • Huang, Pinchia. "Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes." Master's thesis, Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814

    Chicago Manual of Style (17th edition)

case1247627814
3,754
© 2009, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.