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MAVEN: a tool for Visualization and Functional Analysis of Genome-Wide Association Studies

Narayanan, Kanchana
http://rave.ohiolink.edu/etdc/view?acc_num=case1269455528

Abstract Details

2010, Master of Sciences, Case Western Reserve University, EECS - Computer and Information Sciences.
Genome-wide association studies (GWAS) provide a new and powerful approach to investigate the effect of inherited genetic variation on risks of complex diseases. With recent advances in genotyping technology, GWAS are now becoming a reality. Within the past two years, scientists have successfully replicated genetic risks of several complex diseases including cancers, obesity, and type 2 diabetes using GWAS. And more data from GWAS are expected at an accelerated rate. However, management, analysis, visualization, and interpretation of GWAS data are particularly difficult, primarily because GWAS may consist of hundreds of thousands SNPs (single nucleotide polymorphisms) from thousands of individuals. This thesis describes the functionality and implementation of a web application tool, MAVEN for Management, Analysis, Visualization and rEsults shariNg of GWAS data. MAVEN seamlessly integrates users own data with publicly available databases like NCBI, to provide several functional annotations of SNPs and genes that are relevant to their research interests.
Jing Li, Phd (Committee Chair)
Gultekin Ozsoyoglu, PhD (Committee Member)
Guo-Qiang Zhang, PhD (Committee Member)
94 p.
Bioinformatics; Computer Science
Visualization; Genome-wide association studies; Functional Analysis

Recommended Citations

Citations

  • Narayanan, K. (2010). MAVEN: a tool for Visualization and Functional Analysis of Genome-Wide Association Studies [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1269455528

    APA Style (7th edition)

  • Narayanan, Kanchana. MAVEN: a tool for Visualization and Functional Analysis of Genome-Wide Association Studies. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1269455528.

    MLA Style (8th edition)

  • Narayanan, Kanchana. "MAVEN: a tool for Visualization and Functional Analysis of Genome-Wide Association Studies." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1269455528

    Chicago Manual of Style (17th edition)

case1269455528
921
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.